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IF 18.9 1区医学 Q1 ENDOCRINOLOGY & METABOLISM

Nature metabolism Pub Date : 2025-03-05 DOI:10.1038/s42255-025-01241-w

Rushil Shah, Ruoning Wang

引用次数: 0

摘要

天冬酰胺酶（L-ASP）是白血病的标准疗法，但不是实体瘤的标准疗法。Chang等人在一项针对鼻咽癌的同情使用试验中报告说，L-天冬酰胺酶与pembrolizumab联合使用可增强抗肿瘤T细胞反应，并带来临床疗效。这项研究证明了癌症 "代谢免疫疗法 "的概念。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

ASPiring metabolic-immunotherapy by ASParaginase

查看原文本刊更多论文

ASPiring metabolic-immunotherapy by ASParaginase

l-Asparaginase (L-ASP) is a standard therapy for leukemias but not solid tumours. In a compassionate-use trial for nasopharyngeal carcinoma, Chang et al. report that L-ASP enhances the anti-tumour T cell response with clinical benefits when combined with pembrolizumab. This study provides proof of concept for ‘metabolic-immunotherapy’ in cancer.

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来源期刊

Nature metabolism ENDOCRINOLOGY & METABOLISM-

CiteScore

27.50

自引率

2.40%

发文量

170

期刊介绍： Nature Metabolism is a peer-reviewed scientific journal that covers a broad range of topics in metabolism research. It aims to advance the understanding of metabolic and homeostatic processes at a cellular and physiological level. The journal publishes research from various fields, including fundamental cell biology, basic biomedical and translational research, and integrative physiology. It focuses on how cellular metabolism affects cellular function, the physiology and homeostasis of organs and tissues, and the regulation of organismal energy homeostasis. It also investigates the molecular pathophysiology of metabolic diseases such as diabetes and obesity, as well as their treatment. Nature Metabolism follows the standards of other Nature-branded journals, with a dedicated team of professional editors, rigorous peer-review process, high standards of copy-editing and production, swift publication, and editorial independence. The journal has a high impact factor, has a certain influence in the international area, and is deeply concerned and cited by the majority of scholars.