铜催化的化学选择性 C-H 功能化/脱芳烃序列：直接获得吲哚基螺环支架

IF 4.2 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemical Communications Pub Date : 2025-03-12 DOI:10.1039/d5cc00594a

Yuting Zhao , Xin Ji , Yuanjing Xiao , Xingxing Wu , Lu Liu

引用次数: 0

摘要

本文通过化学选择性C-H功能化/脱芳化序列，建立了铜催化吲哚与炔基重氮酮的分子间[4+1]旋环反应。在这个方案中，各种吲哚基的螺旋环分子可以得到良好的产率，具有优异的化学选择性和中等至良好的非对映选择性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Copper-catalyzed chemoselective C–H functionalization/dearomatization sequence: direct access to indole-based spirocyclic scaffolds†

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Copper-catalyzed chemoselective C–H functionalization/dearomatization sequence: direct access to indole-based spirocyclic scaffolds†

Herein, a copper-catalyzed intermolecular [4+1] spiroannulation of indoles with alkynyldiazoketones affording various indole-based spirocyclic molecules via a chemoselective C–H functionalization/dearomatization sequence was developed.

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来源期刊

Chemical Communications 化学-化学综合

CiteScore

8.60

自引率

4.10%

发文量

2705

审稿时长

1.4 months

期刊介绍： ChemComm (Chemical Communications) is renowned as the fastest publisher of articles providing information on new avenues of research, drawn from all the world''s major areas of chemical research.