一个历史性的病例复发缓解阿尔茨海默病在一个青少年归因于猩红热。

IF 2.8 Q2 NEUROSCIENCES
Journal of Alzheimer's disease reports Pub Date : 2025-01-14 eCollection Date: 2025-01-01 DOI:10.1177/25424823241298530
Richard Lathe, Brian Balin
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引用次数: 0

摘要

我们提请注意一个历史案例,一个男孩在7岁时患有猩红热(通常由细菌化脓性链球菌引起),并继续发展为阿尔茨海默病(AD)的症状。他的医生认为随后的痴呆与感染有关。24岁死亡后,尸检发现大量AD型老年斑和原纤维,正式确认AD。本文还讨论了早发性痴呆的其他潜在原因,但这些原因与E.H.患者不同。这个病例与当前关于感染在AD中的潜在作用的争论有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A historic case of relapsing-remitting Alzheimer's disease in an adolescent attributed to scarlet fever.

We draw attention to a historic case of a boy who suffered from scarlet fever (typically caused by the bacterium Streptococcus pyogenes) at age 7 years and went on to develop the symptoms of Alzheimer's disease (AD). His physicians believed that the subsequent dementia was related to the infection. After death at 24 years of age, postmortem brain examination revealed abundant AD-type senile plaques and fibrils, formally confirming AD. Other potential causes of early-onset dementia are discussed, but these are distinct from patient E.H. This case is pertinent regarding the current debate about the potential role of infection in AD.

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