免疫治疗中的光基技术:进展、机制和应用。

IF 2.7 4区 医学 Q3 IMMUNOLOGY
Immunotherapy Pub Date : 2025-02-01 Epub Date: 2025-03-03 DOI:10.1080/1750743X.2025.2470111
Davide Frumento, Ștefan Ţălu
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引用次数: 0

摘要

基于光的免疫疗法使用特定波长的光来激活或调节免疫反应。它主要采用两种机制:直接激活免疫细胞和间接调节肿瘤微环境(TME)。几种基于光的技术正在研究或临床应用于免疫治疗,包括光动力免疫疗法(PDIT)和光热疗法(PTT)。光遗传学工具具有精确控制t细胞受体激活、细胞因子释放或其他免疫效应细胞活性的潜力。基于光的技术在免疫治疗领域提供了创新的机会。通过光遗传学精确调节免疫细胞激活的能力,以及通过光免疫疗法改善癌细胞的靶向性,标志着我们免疫调节策略的革命性转变。虽然这些技术中的许多仍处于各种应用的实验阶段,但初步发现令人鼓舞,特别是在癌症治疗和免疫调节方面。持续的研究和临床试验对于在免疫细胞治疗的背景下充分利用光技术的能力至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Light-based technologies in immunotherapy: advances, mechanisms and applications.

Light-based immunotherapy uses specific wavelengths of light to activate or modulate immune responses. It primarily employs two mechanisms: direct activation of immune cells and indirect modulation of the tumor microenvironment (TME). Several light-based technologies are under investigation or clinical use in immunotherapy, including photodynamic immunotherapy (PDIT) and photothermal therapy (PTT). Optogenetic tools have the potential to precisely control T-cell receptor activation, cytokine release, or the activity of other immune effector cells. Light-based technologies present innovative opportunities within the realm of immunotherapy. The ability to precisely regulate immune cell activation via optogenetics, alongside the improved targeting of cancer cells through photoimmunotherapy, signifies a transformative shift in our strategies for immune modulation. Although many of these technologies remain in the experimental stage for various applications, initial findings are encouraging, especially concerning cancer treatment and immune modulation. Continued research and clinical trials are essential to fully harness the capabilities of light technology in the context of immune cell therapy.

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来源期刊
Immunotherapy
Immunotherapy 医学-免疫学
CiteScore
5.00
自引率
3.60%
发文量
113
审稿时长
6-12 weeks
期刊介绍: Many aspects of the immune system and mechanisms of immunomodulatory therapies remain to be elucidated in order to exploit fully the emerging opportunities. Those involved in the research and clinical applications of immunotherapy are challenged by the huge and intricate volumes of knowledge arising from this fast-evolving field. The journal Immunotherapy offers the scientific community an interdisciplinary forum, providing them with information on the most recent advances of various aspects of immunotherapies, in a concise format to aid navigation of this complex field. Immunotherapy delivers essential information in concise, at-a-glance article formats. Key advances in the field are reported and analyzed by international experts, providing an authoritative but accessible forum for this vitally important area of research. Unsolicited article proposals are welcomed and authors are required to comply fully with the journal''s Disclosure & Conflict of Interest Policy as well as major publishing guidelines, including ICMJE and GPP3.
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