哈密卫矛根新发现的二萜及其对人癌细胞的细胞毒性。

IF 2.5 4区医学 Q3 CHEMISTRY, MEDICINAL

Journal of Natural Medicines Pub Date : 2025-03-01 DOI:10.1007/s11418-025-01887-6

Jungmoo Huh, Eun Jin Park, Jae Hyun Lee, Chan-Woong Park, Tae-Jin Yang, Won Keun Oh, Young-Won Chin

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引用次数: 0

摘要

从 Euonymus hamiltonianus 的根中分离出了两种新的阿比坦类二萜，即 6β-（3-呋喃基氧基）阿魏酰醇（1）和 6-氯-6,7-脱氢阿魏酰醇（2），以及五种已知的二萜（3-7）。通过各种光谱分析，包括 HRMS、1D 和 2D NMR 以及 ECD 分析，对这些化合物的结构进行了表征。评估了所有分离化合物（1-7）对人结肠癌细胞系 HCT116 的细胞毒性活性，发现它们具有中等程度的细胞毒性活性，IC50 值在 4.5 到 22.9 μM 之间。在分离出的化合物中，与其他分离出的化合物相比，montbretol (4) 对 HCT116 人结肠癌细胞的细胞毒活性最高（IC50 = 4.50 ± 0.29 μM）。

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New abietane-type diterpenoids from roots of Euonymus hamiltonianus and their cytotoxicity in human cancer cell.

Two new abietane-type diterpenoids, 6β-(3-furoyloxy)ferruginol (1) and 6-chloro-6,7-dehydroferruginol (2), were isolated from the roots of Euonymus hamiltonianus along with five known diterpenoids (3-7). Their structures were characterized using various spectroscopic analysis including HRMS, 1D and 2D NMR, and ECD analysis. All isolated compounds (1-7) were evaluated for their cytotoxic activity against human colon cancer cell line, HCT116, and it was found to exhibit moderate cytotoxic activity with IC₅₀ values ranging from 4.5 to 22.9 μM. Among the isolated compounds, montbretol (4) displayed the most cytotoxic activity (IC₅₀ = 4.50 ± 0.29 μM) against HCT116 human colon cancer cells than the other isolated compounds.

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来源期刊

Journal of Natural Medicines 医学-药学

CiteScore

6.90

自引率

3.00%

发文量

审稿时长

1.7 months

期刊介绍： The Journal of Natural Medicines is an international journal publishing original research in naturally occurring medicines and their related foods and cosmetics. It covers: -chemistry of natural products -biochemistry of medicinal plants -pharmacology of natural products and herbs, including Kampo formulas and traditional herbs -botanical anatomy -cultivation of medicinal plants. The journal accepts Original Papers, Notes, Rapid Communications and Natural Resource Letters. Reviews and Mini-Reviews are generally invited.