鉴定致病性PD-1+CD8+ T细胞在小鼠Sjögren病模型中的有效嵌合抗原受体治疗

IF 11.4 1区医学 Q1 RHEUMATOLOGY

Arthritis & Rheumatology Pub Date : 2025-03-03 DOI:10.1002/art.43144

Jin-Fen Ma, Ting Xu, Hao-Xian Zhu, Xiao-Min Chen, Liang Li, Zhi-Bin Zhao, Liwei Lu, Yang Li, Zhe-Xiong Lian, Cai-Yue Gao

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引用次数: 0

摘要

活化T细胞在Sjögren病（SjD）的进展中起关键的致病作用；然而，目前还没有专门针对它们的靶向治疗方法。本研究旨在鉴定SjD的致病CD8+ T细胞，并制定有针对性的治疗策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Identification of pathogenic PD-1+CD8+ T cells for effective chimeric antigen receptor therapy in a murine model of Sjögren's disease

Activated T cells play a pivotal pathogenic role in the progression of Sjögren's disease (SjD); however, there are currently no targeted therapies specifically designed to address them. This study aims to identify pathogenic CD8⁺ T cells in SjD and develop targeted therapeutic strategies.

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来源期刊

Arthritis & Rheumatology RHEUMATOLOGY-

CiteScore

20.90

自引率

3.00%

发文量

371

期刊介绍： Arthritis & Rheumatology is the official journal of the American College of Rheumatology and focuses on the natural history, pathophysiology, treatment, and outcome of rheumatic diseases. It is a peer-reviewed publication that aims to provide the highest quality basic and clinical research in this field. The journal covers a wide range of investigative areas and also includes review articles, editorials, and educational material for researchers and clinicians. Being recognized as a leading research journal in rheumatology, Arthritis & Rheumatology serves the global community of rheumatology investigators and clinicians.