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引用次数: 0
摘要
研究背景本研究旨在阐明急性主动脉夹层（AD）和冠心病（CHD）患者体内血管紧张素转换酶（ACE）和ACE2的表达水平及其基因多态性之间的区别：方法：研究人员招募了86名患者，其中包括34名急性主动脉夹层患者（包括斯坦福A型和B型）、18名升主动脉瘤患者、21名冠心病患者和13名健康对照者。44名患者的主动脉组织样本是在手术治疗过程中采集的：升主动脉瘤组、CHD 组和对照组的 ACE 和 ACE2 表达水平有明显统计学差异（p p p 结论：血浆 ACE 水平、ACE2 和 ACE2 表达水平在升主动脉瘤组、CHD 组和对照组之间有明显统计学差异（p p p急性 AD 患者的血浆 ACE 水平以及 ACE 和 ACE2 的基因表达明显降低。观察到的 ACE 和 ACE2 表达失衡可能在 AD 的发病机制中起着关键作用。
Analysis of angiotensin-converting enzyme (ACE), ACE2, and their genetic polymorphisms in patients with acute aortic dissection and coronary heart disease.
Background: This study aimed to elucidate the distinctions between the expression levels of angiotensin-converting enzyme (ACE) and ACE2, as well as their genetic polymorphisms, in patients with acute aortic dissection (AD) and coronary heart disease (CHD).
Methods: A cohort of 86 patients was enrolled, comprising 34 individuals with acute AD (encompassing Stanford types A and B), 18 with ascending aortic aneurysm, 21 with CHD, and 13 healthy controls. Aortic tissue samples were procured from 44 patients during surgical interventions.
Results: Statistically significant differences were observed in ACE and ACE2 expression levels among the ascending aortic aneurysm, CHD, and control groups (p < 0.05). However, the expression of ACE messenger ribonucleic acid (mRNA) in the aortic wall was significantly higher in the AD group than in the ascending aortic aneurysm and CHD groups (p < 0.05). Additionally, the expression of ACE2 mRNA and the ACE/ACE2 ratio in the aortic wall were significantly different in the AD group compared with the ascending aortic aneurysm and CHD groups (p < 0.05).
Conclusion: Plasma ACE levels, and the gene expressions of ACE and ACE2, are markedly reduced in patients with acute AD. The observed imbalance in ACE and ACE2 expressions may play a pivotal role in the pathogenesis of AD.
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