肠和胰腺内分泌细胞中的嗜铬颗粒蛋白A和B和分泌颗粒蛋白II。

Basic and applied histochemistry Pub Date : 1988-01-01
R Buffa, P Marè, A Gini, M Salvadore
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引用次数: 0

摘要

嗜铬颗粒蛋白A、B和分泌颗粒蛋白II广泛存在于胃肠道胰腺内分泌/旁分泌细胞中。胰高血糖素-、PP-、胃泌素-、胃泌素- cck -、分泌素-免疫反应细胞均表现出嗜铬蛋白A的免疫反应性,其中肠嗜铬蛋白细胞的染色最强烈。在胃泌素细胞和胰高血糖素细胞以及一些含有胰高血糖素A的肠嗜铬细胞中检测到嗜铬粒蛋白B的免疫反应性。分泌嗜铬粒蛋白II在胰岛胰高血糖素细胞中与嗜铬粒蛋白A配对,或单独出现在结肠粘膜胰高血糖素/PP细胞中。到目前为止,在生长抑素、GIP或运动素免疫反应细胞中均未检测到嗜铬粒蛋白和分泌粒蛋白II。嗜银性ECL细胞中检出嗜铬粒蛋白A,但未检出嗜铬粒蛋白B或分泌型嗜铬粒蛋白II。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Chromogranins A and B and secretogranin II in hormonally identified endocrine cells of the gut and the pancreas.

Chromogranins A and B and secretogranin II have been localized in a wide spectrum of gastroenteropancreatic endocrine/paracrine cells. Chromogranin A immunoreactivity showed the widest distribution and was displayed by glucagon-, PP-, gastrin-, gastrin-CCK-, secretin-immunoreactive cells, the most intense stainings being peculiar of enterochromaffin cells. Chromogranin B immunoreactivity was detected in gastrin- and glucagon cells and in some enterochromaffin cells containing also chromogranin A. Secretogranin II was paired to chromogranin A in glucagon cells of pancreatic islets or occurred alone in glycentin/PP cells of colonic mucosa. Neither of the chromogranins nor secretogranin II have been so far detected in somatostatin-, GIP-, or motilin-immunoreactive cells. Chromogranin A but not chromogranin B or secretogranin II has been detected in the gastric argyrophilic ECL cells.

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