不同体育锻炼作为抗衰老因子在不同干细胞中的作用。

IF 4.4 4区 医学 Q1 GERIATRICS & GERONTOLOGY
Jia Xu, Zhe Song
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引用次数: 0

摘要

衰老过程与细胞衰老的特点有关。了解它们的因果网络有助于建立一个框架,创造新的治疗方法,以减缓衰老过程。越来越多的研究表明,衰老可能会对干细胞(SCs)产生不利影响。SCs会改变其分化为不同细胞类型的能力,并随着年龄的增长而降低其更新的潜力。研究表明,持续的体育锻炼对健康有很多好处,包括降低患肿瘤、心脏病、糖尿病和神经系统疾病等与年龄有关的疾病的风险。运动是一种强有力的生理压力源,与更高的红细胞计数和增强的免疫系统有关,促进疾病抵抗。运动影响间充质SCs (MSCs)、造血SCs (hsc)、神经元SCs (NuSCs)和肌肉SCs (MuSCs)以及其他老化的SCs类型。这些生态位的变化可能会影响运动后成人SCs的数量和能力。在这项工作中,我们研究了不同类型的sc是如何老化的。体育活动对衰老过程的影响已被研究过。此外,不同运动和体育活动对sc作为抗衰老成分的影响也有讨论和研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The role of different physical exercises as an anti-aging factor in different stem cells.

The senescence process is connected to the characteristics of cellular aging. Understanding their causal network helps develop a framework for creating new treatments to slow down the senescence process. A growing body of research indicates that aging may adversely affect stem cells (SCs). SCs change their capability to differentiate into different cell types and decrease their potential for renewal as they age. Research has indicated that consistent physical exercise offers several health advantages, including a reduced risk of age-associated ailments like tumors, heart disease, diabetes, and neurological disorders. Exercise is a potent physiological stressor linked to higher red blood cell counts and an enhanced immune system, promoting disease resistance. Sports impact mesenchymal SCs (MSCs), hematopoietic SCs (HSCs), neuronal SCs (NuSCs), and muscular SCs (MuSCs), among other aged SCs types. These changes to the niche will probably affect the amount and capability of adult SCs after exercise. In this work, we looked into how different types of SCs age. The impact of physical activity on the aging process has been studied. Additionally, there has been discussion and study on the impact of different sports and physical activities on SCs as an anti-aging component.

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来源期刊
Biogerontology
Biogerontology 医学-老年医学
CiteScore
8.00
自引率
4.40%
发文量
54
审稿时长
>12 weeks
期刊介绍: The journal Biogerontology offers a platform for research which aims primarily at achieving healthy old age accompanied by improved longevity. The focus is on efforts to understand, prevent, cure or minimize age-related impairments. Biogerontology provides a peer-reviewed forum for publishing original research data, new ideas and discussions on modulating the aging process by physical, chemical and biological means, including transgenic and knockout organisms; cell culture systems to develop new approaches and health care products for maintaining or recovering the lost biochemical functions; immunology, autoimmunity and infection in aging; vertebrates, invertebrates, micro-organisms and plants for experimental studies on genetic determinants of aging and longevity; biodemography and theoretical models linking aging and survival kinetics.
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