Mauro Zaccarelli, Claudia Minosse, Silvia Pauciullo, Massimiliano Scuderi, Fabio Gemelli, Giuseppe Tacchi, Giovanna Giacchetti, Mauro Marchili, Valentina D'Ovidio, Anna Rosa Garbuglia
{"title":"列埃蒂市（意大利拉齐奥）一例严重戊型肝炎病例：与2019年聚集性病例相关，表明存在常住戊型肝炎病毒株；一份病例报告。","authors":"Mauro Zaccarelli, Claudia Minosse, Silvia Pauciullo, Massimiliano Scuderi, Fabio Gemelli, Giuseppe Tacchi, Giovanna Giacchetti, Mauro Marchili, Valentina D'Ovidio, Anna Rosa Garbuglia","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Hepatitis E is generally considered a mild disease, but severe cases are also observed. In high-income countries, most hepatitis E cases are due to HEV genotype 3 and are linked mainly to the consumption of pork or wild boar meat, but data on the correlation of viral variants and hepatitis severity are still preliminary. We described a serious acute hepatitis E (Genotype 3e) case observed in the city of Rieti (Lazio region, Italy), and compared it with previous cases found in the same geographical area. Phylogenetic analysis of open reading frame 2 (ORF2) showed that the HEV strain of the patient in Rieti is closely related to those identified in the acute HEV hepatitis outbreak in 2019. Our data suggest the need to strengthen surveillance and prevention against HEV infection and investigation of pathogenicity linked to specific HEV variants.</p>","PeriodicalId":54723,"journal":{"name":"New Microbiologica","volume":"47 4","pages":"358-362"},"PeriodicalIF":1.5000,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A serious hepatitis E case in the city of Rieti (Lazio, Italy): correlation with a 2019 cluster suggests a resident hepatitis E virus strain; a case report.\",\"authors\":\"Mauro Zaccarelli, Claudia Minosse, Silvia Pauciullo, Massimiliano Scuderi, Fabio Gemelli, Giuseppe Tacchi, Giovanna Giacchetti, Mauro Marchili, Valentina D'Ovidio, Anna Rosa Garbuglia\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Hepatitis E is generally considered a mild disease, but severe cases are also observed. In high-income countries, most hepatitis E cases are due to HEV genotype 3 and are linked mainly to the consumption of pork or wild boar meat, but data on the correlation of viral variants and hepatitis severity are still preliminary. We described a serious acute hepatitis E (Genotype 3e) case observed in the city of Rieti (Lazio region, Italy), and compared it with previous cases found in the same geographical area. Phylogenetic analysis of open reading frame 2 (ORF2) showed that the HEV strain of the patient in Rieti is closely related to those identified in the acute HEV hepatitis outbreak in 2019. Our data suggest the need to strengthen surveillance and prevention against HEV infection and investigation of pathogenicity linked to specific HEV variants.</p>\",\"PeriodicalId\":54723,\"journal\":{\"name\":\"New Microbiologica\",\"volume\":\"47 4\",\"pages\":\"358-362\"},\"PeriodicalIF\":1.5000,\"publicationDate\":\"2024-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"New Microbiologica\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"MICROBIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"New Microbiologica","FirstCategoryId":"3","ListUrlMain":"","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"MICROBIOLOGY","Score":null,"Total":0}
A serious hepatitis E case in the city of Rieti (Lazio, Italy): correlation with a 2019 cluster suggests a resident hepatitis E virus strain; a case report.
Hepatitis E is generally considered a mild disease, but severe cases are also observed. In high-income countries, most hepatitis E cases are due to HEV genotype 3 and are linked mainly to the consumption of pork or wild boar meat, but data on the correlation of viral variants and hepatitis severity are still preliminary. We described a serious acute hepatitis E (Genotype 3e) case observed in the city of Rieti (Lazio region, Italy), and compared it with previous cases found in the same geographical area. Phylogenetic analysis of open reading frame 2 (ORF2) showed that the HEV strain of the patient in Rieti is closely related to those identified in the acute HEV hepatitis outbreak in 2019. Our data suggest the need to strengthen surveillance and prevention against HEV infection and investigation of pathogenicity linked to specific HEV variants.
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The publication, diffusion and furtherance of research and study on all aspects of basic and clinical Microbiology and related fields are the chief aims of the journal.
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