Ni(II)-催化α-氟酯的对映选择性α-肼化：手性季α-氟化α-氨基酸衍生物的制备

Organic chemistry frontiers : an international journal of organic chemistry Pub Date : 2025-02-12 DOI:10.1039/d4qo02418d

Wei-Jing Yang , Jun-Hao Zhang , Ning Li , Ming-Sheng Xie , Hai-Ming Guo

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引用次数: 0

摘要

以偶氮二羧酸盐为亲电胺化剂，对α-氮杂杨基-α-氟酯进行了高催化不对称α-胺化反应。以c1对称咪唑烷-吡咯咪唑酮吡啶为三齿配体，Ni(BF4)2·6H2O为Lewis酸，以高收率（高达97%）和优异的对映选择性（高达98% ee）得到了手性α-肼基-α-氟化酯衍生物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Ni(ii)-catalyzed enantioselective α-hydrazination of α-fluoroesters: access to chiral quaternary α-fluorinated α-amino acid derivatives†

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Ni(ii)-catalyzed enantioselective α-hydrazination of α-fluoroesters: access to chiral quaternary α-fluorinated α-amino acid derivatives†

A highly catalytic asymmetric α-amination of α-azaaryl-α-fluoro esters with azodicarboxylates as the electrophilic aminating agents was reported. With C₁-symmetric imidazolidine-pyrroloimidazolone pyridine as the tridentate ligand and Ni(BF₄)₂·6H₂O as the Lewis acid, diverse chiral α-hydrazino-α-fluorinated ester derivatives were obtained in high yields (up to 97% yield) and excellent enantioselectivities (up to 98% ee).

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来源期刊

Organic chemistry frontiers : an international journal of organic chemistry

CiteScore

7.80

自引率

0.00%

发文量