干细胞的昼夜节律及其治疗潜力。

IF 7.1 2区 医学 Q1 CELL & TISSUE ENGINEERING
Napasiri Putthanbut, Paul Alexis Bourgade Su, Jea-Young Lee, Cesario V Borlongan
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引用次数: 0

摘要

昼夜节律几乎存在于所有细胞中,但其在干细胞中的存在尚未得到很好的证实。生物钟似乎与成熟细胞的分化密切相关,在未成熟胚胎干细胞中很少被发现。最近的证据表明,干细胞中存在昼夜节律基因和节律性生理活动,以及干细胞衍生的细胞外囊泡(EV)特征。生物钟包含多种生理和病理机制,是细胞命运的基础。将昼夜节律整合到临床应用中,如时间疗法、时间生物标志物和环境修饰,可能促进基于干细胞的再生医学的治疗效果。了解干细胞的昼夜节律可以通过确定干细胞的最佳采集和管理时间来优化干细胞治疗,从而提高治疗效果。对干细胞昼夜节律特性的进一步研究将改进基于干细胞的治疗方法,促进再生医学的进步。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Circadian rhythms in stem cells and their therapeutic potential.

Circadian rhythms are present in almost all cells, but their existence in stem cells has remains not well established. Circadian clock appears to be closely associated with differentiated mature cells and rarely detected in immature embryonic stem cells. Recent evidence reveals the presence of circadian genes and rhythmic physiologic activities in stem cells as well as stem cell-derived extracellular vesicle (EV) characteristics. The circadian clock entails diverse physiologic and pathological mechanisms underlying cell fate. Integration of circadian rhythm to clinical applications, such as chronotherapy, chrono-biomarker, and environment modification, may facilitate therapeutic outcomes of stem cell-based regenerative medicine. Understanding circadian rhythms in stem cells can optimize stem cell-based therapies by determining the best times for harvesting and administering stem cells, thereby enhancing therapeutic efficacy. Further research into the circadian properties of stem cells will refine stem cell-based therapies, contributing to advancements in regenerative medicine.

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来源期刊
Stem Cell Research & Therapy
Stem Cell Research & Therapy CELL BIOLOGY-MEDICINE, RESEARCH & EXPERIMENTAL
CiteScore
13.20
自引率
8.00%
发文量
525
审稿时长
1 months
期刊介绍: Stem Cell Research & Therapy serves as a leading platform for translational research in stem cell therapies. This international, peer-reviewed journal publishes high-quality open-access research articles, with a focus on basic, translational, and clinical research in stem cell therapeutics and regenerative therapies. Coverage includes animal models and clinical trials. Additionally, the journal offers reviews, viewpoints, commentaries, and reports.
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