GLUT4、LEPR和TNF-a与多囊卵巢综合征所致不孕妇女子宫内膜容受性的相关性

IF 2 4区医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Medical Biochemistry Pub Date : 2025-01-24 DOI:10.5937/jomb0-51125

Dong Yan, Wei Kong, Li Yifei, Liu Yan, Li Lin, Li Yan

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引用次数: 0

摘要

背景：分析葡萄糖转运蛋白4 （GLUT4）、瘦素受体（LEPR）、肿瘤坏死因子-α (TNF-α)与多囊卵巢综合征（PCOS）不孕患者子宫内膜容受性（ER）的相关性，为今后多囊卵巢综合征（PCOS）不孕的诊断和治疗提供临床依据。方法：前瞻性纳入2020年6月至2023年8月山东中医药大学附属第二医院收治的109例研究对象，其中PCOS致不孕症患者42例（研究组），单纯性PCOS非妊娠患者35例（对照组），非妊娠健康女性32例（正常组）。检测所有受试者外周血GLUT4、LEPR、TNF-α水平，分析其对健康女性PCOS及PCOS致不孕的诊断价值。同时测量研究组患者子宫内膜厚度、子宫内膜血流脉动指数（PI）和阻力指数（RI）。此外，我们还讨论了GLUT4、LEPR、TNF-α与ER的相关性。结果：研究组GLUT4较对照组和正常组低，LEPR、TNF-α较高(p结论：GLUT4、LEPR、TNF-α与PCOS不孕患者ER密切相关，三者联合检测可有效评价PCOS及PCOS不孕的发生。

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Correlation of GLUT4, LEPR , and TNF-a with endometrial receptivity in women with polycystic ovarian syndrome-induced infertility.

Background: To analyze the correlation of glucose transporter 4 (GLUT4), leptin receptor (LEPR), and tumour necrosis factor-a (TNF-α) with endometrial receptivity (ER) in patients with polycystic ovarian syndrome (PCOS)induced infertility to provide clinical evidence for future diagnosis and treatment of PCOS-induced infertility.

Methods: We prospectively enrolled 109 study subjects admitted to The Second Hospital Affiliated of Shandong University of Traditional Chinese Medicine from June 2020 to August 2023, including 42 patients with PCOS-induced infertility (research group), 35 nonpregnant patients with simple PCOS (control group), and 32 nonpregnant healthy women (normal group). GLUT4, LEPR, and TNF-α levels in the peripheral blood were detected in all participants, and their diagnostic value for PCOS in healthy women and PCOS-induced infertility in PCOS patients was analyzed. In addition, the endometrial thickness and endometrial blood flow pulsation index (PI) and resistance index (RI) of patients in the research group were measured. Furthermore, the correlation of GLUT4, LEPR, and TNF-α with ER was discussed.

Results: GLUT4 was lower in the research group compared with the control and normal groups, while LEPR and TNF-α were higher (P<0.05); the control group showed lower GLUT4 and higher LEPR and TNF-α levels than the normal group (P<0.05). The diagnostic sensitivity and specificity of GLUT4, LEPR, and TNF-α combined assay for PCOSinduced infertility in PCOS women were 88.57% and 75.00%, respectively, and those for PCOS in healthy women were 78.57% and 60.00%, respectively (P<0.05). In the research group, GLUT4 was positively correlated with endometrial thickness and negatively linked to RI and PI. At the same time, LEPR and TNF-α were negatively associated with endometrial thickness and positively correlated with RI and PI (P<0.05).

Conclusions: GLUT4, LEPR, and TNF-α are closely related to ER in patients with PCOS-induced infertility, and their combined detection can effectively evaluate the occurrence of PCOS and PCOS-induced infertility.

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来源期刊

Journal of Medical Biochemistry BIOCHEMISTRY & MOLECULAR BIOLOGY-

CiteScore

3.00

自引率

12.00%

发文量

审稿时长

>12 weeks

期刊介绍： The JOURNAL OF MEDICAL BIOCHEMISTRY (J MED BIOCHEM) is the official journal of the Society of Medical Biochemists of Serbia with international peer-review. Papers are independently reviewed by at least two reviewers selected by the Editors as Blind Peer Reviews. The Journal of Medical Biochemistry is published quarterly. The Journal publishes original scientific and specialized articles on all aspects of clinical and medical biochemistry, molecular medicine, clinical hematology and coagulation, clinical immunology and autoimmunity, clinical microbiology, virology, clinical genomics and molecular biology, genetic epidemiology, drug measurement, evaluation of diagnostic markers, new reagents and laboratory equipment, reference materials and methods, reference values, laboratory organization, automation, quality control, clinical metrology, all related scientific disciplines where chemistry, biochemistry, molecular biology and immunochemistry deal with the study of normal and pathologic processes in human beings.