Guangtang Chen, Yi Cao, Xiaolin Du, Junshuan Cui, Xi Zeng, Hua Yang, Zeguang Ren, Kaya Xu
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Bibliometric and visualization analyses were conducted using the online tools of the WoSCC database and CiteSpace 6.2.R6.</p><p><strong>Results: </strong>Analysis of 28 articles published by 158 researchers from 55 institutions across 8 countries revealed an intermittent small-scale growth in annual publication volume from 1994 to 2024, with a continuous rise in annual citation volume since 2005, indicating growing interest in the field. Japan, Germany, and the United States of America (USA) were the most prolific and influential countries. Institutions such as Tokyo Women's Medical University showed particularly significant contributions. Kasuya Hidetoshi was the most prolific author. There was little global collaboration among countries, institutions, and authors, with distinct regional research characteristics: Japan and Germany focused on intracranial implants, while the USA concentrated on intrathecal injections. Major publishing and co-cited journals included <i>Neurocritical Care, Acta Neurochirurgica, Journal of Neurosurgery</i>, and <i>Stroke</i>. Popular keywords in 2024 included \"preventing cerebral vasospasm\", \"delayed cerebral ischemia\", \"outcome events\", and \"clinical trials\", revealing current research hotspots.</p><p><strong>Conclusion: </strong>This study maps the global clinical research landscape of intracranial application of nicardipine for aSAH from 1994 to 2024, providing valuable references and guidance for future research.</p>","PeriodicalId":11290,"journal":{"name":"Drug Design, Development and Therapy","volume":"19 ","pages":"1129-1146"},"PeriodicalIF":4.7000,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11847436/pdf/","citationCount":"0","resultStr":"{\"title\":\"The Clinical Research Landscape of Intracranial Nicardipine for Aneurysmal Subarachnoid Hemorrhage: Insights From Bibliometric Analysis.\",\"authors\":\"Guangtang Chen, Yi Cao, Xiaolin Du, Junshuan Cui, Xi Zeng, Hua Yang, Zeguang Ren, Kaya Xu\",\"doi\":\"10.2147/DDDT.S503226\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>The 2023 American Heart Association/American Stroke Association guideline and Wessels et al's 2024 randomized controlled trial highlight the potential benefits of intracranial nicardipine for aneurysmal subarachnoid hemorrhage (aSAH). 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引用次数: 0
摘要
背景：2023年美国心脏协会/美国卒中协会指南和Wessels等人的2024年随机对照试验强调了颅内尼地平治疗动脉瘤性蛛网膜下腔出血（aSAH）的潜在益处。本研究旨在通过文献计量学分析，系统识别该领域的出版趋势和研究热点。方法：相关文献来源于Web of Science Core Collection （WoSCC）。采用WoSCC数据库和CiteSpace 6.2.R6在线工具进行文献计量和可视化分析。结果：对来自8个国家55个机构的158名研究人员发表的28篇论文的分析显示，1994年至2024年，年出版量呈间歇性小规模增长，自2005年以来，年被引量持续上升，表明人们对该领域的兴趣越来越大。日本、德国和美利坚合众国（美国）是最多产和最有影响力的国家。东京女子医科大学等机构做出了特别重大的贡献。Kasuya Hidetoshi是最多产的作家。国家、机构和作者之间的全球合作很少，具有明显的区域研究特征：日本和德国侧重于颅内植入物，而美国侧重于鞘内注射。主要出版和共同引用的期刊包括《神经危重症护理》、《神经外科学报》、《神经外科杂志》和《中风》。2024年的热门关键词包括“预防脑血管痉挛”、“迟发性脑缺血”、“结局事件”和“临床试验”，揭示了当前的研究热点。结论：本研究绘制了1994 - 2024年全球尼卡地平颅内应用治疗aSAH的临床研究概况，为今后的研究提供了有价值的参考和指导。
The Clinical Research Landscape of Intracranial Nicardipine for Aneurysmal Subarachnoid Hemorrhage: Insights From Bibliometric Analysis.
Background: The 2023 American Heart Association/American Stroke Association guideline and Wessels et al's 2024 randomized controlled trial highlight the potential benefits of intracranial nicardipine for aneurysmal subarachnoid hemorrhage (aSAH). This study aims to systematically identify the publication trends and research hotspots in this field through bibliometric analysis.
Methods: Relevant publications were sourced from the Web of Science Core Collection (WoSCC). Bibliometric and visualization analyses were conducted using the online tools of the WoSCC database and CiteSpace 6.2.R6.
Results: Analysis of 28 articles published by 158 researchers from 55 institutions across 8 countries revealed an intermittent small-scale growth in annual publication volume from 1994 to 2024, with a continuous rise in annual citation volume since 2005, indicating growing interest in the field. Japan, Germany, and the United States of America (USA) were the most prolific and influential countries. Institutions such as Tokyo Women's Medical University showed particularly significant contributions. Kasuya Hidetoshi was the most prolific author. There was little global collaboration among countries, institutions, and authors, with distinct regional research characteristics: Japan and Germany focused on intracranial implants, while the USA concentrated on intrathecal injections. Major publishing and co-cited journals included Neurocritical Care, Acta Neurochirurgica, Journal of Neurosurgery, and Stroke. Popular keywords in 2024 included "preventing cerebral vasospasm", "delayed cerebral ischemia", "outcome events", and "clinical trials", revealing current research hotspots.
Conclusion: This study maps the global clinical research landscape of intracranial application of nicardipine for aSAH from 1994 to 2024, providing valuable references and guidance for future research.
期刊介绍：
Drug Design, Development and Therapy is an international, peer-reviewed, open access journal that spans the spectrum of drug design, discovery and development through to clinical applications.
The journal is characterized by the rapid reporting of high-quality original research, reviews, expert opinions, commentary and clinical studies in all therapeutic areas.
Specific topics covered by the journal include:
Drug target identification and validation
Phenotypic screening and target deconvolution
Biochemical analyses of drug targets and their pathways
New methods or relevant applications in molecular/drug design and computer-aided drug discovery*
Design, synthesis, and biological evaluation of novel biologically active compounds (including diagnostics or chemical probes)
Structural or molecular biological studies elucidating molecular recognition processes
Fragment-based drug discovery
Pharmaceutical/red biotechnology
Isolation, structural characterization, (bio)synthesis, bioengineering and pharmacological evaluation of natural products**
Distribution, pharmacokinetics and metabolic transformations of drugs or biologically active compounds in drug development
Drug delivery and formulation (design and characterization of dosage forms, release mechanisms and in vivo testing)
Preclinical development studies
Translational animal models
Mechanisms of action and signalling pathways
Toxicology
Gene therapy, cell therapy and immunotherapy
Personalized medicine and pharmacogenomics
Clinical drug evaluation
Patient safety and sustained use of medicines.
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