植物药及其提取成分抑制流感病毒的研究进展。

IF 2.5 4区医学 Q3 CHEMISTRY, MEDICINAL

Bioorganic & Medicinal Chemistry Letters Pub Date : 2025-02-21 DOI:10.1016/j.bmcl.2025.130151

Jiejie Lu , Zhenzhen Liu , Ziyan Li , Jiahui Su , Haojie Zhen , Ying Qu , Piet Herdewijn , Hongmin Liu , Ying Liu , Zhenya Wang

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引用次数: 0

摘要

流感是一种由流感病毒引起的高度流行和高度传染性的肺部疾病。主要的抗流感策略是疫苗接种和抗病毒药物。疫苗接种是一种有效的预防手段，但研究和开发的时间滞后使得难以立即对疫情作出反应。批准的药物主要是神经氨酸酶和M2离子通道的抑制剂，但由于流感病毒的变异性，可能会出现对这些药物的耐药性。植物药及其提取物在流感治疗中显示出独特的优势，并在中国各地的诊所广泛使用。然而，关于用草药预防和治疗流感的综述很少。我们对近年来的相关文献进行了综述，分析了各种植物药及其提取物在预防和治疗流感中的研究进展。本研究为植物性药物预防和治疗流感提供了理论支持，也为开发新型低毒多靶点药物提供了新思路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

A review-plant medicine and its extraction components inhibit influenza virus

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A review-plant medicine and its extraction components inhibit influenza virus

Influenza is a highly prevalent and highly contagious lung disease caused by influenza viruses. The main anti-influenza strategies are vaccination and antiviral drugs. Vaccination is an effective means of prevention, but the time lag in research and development makes it difficult to respond immediately to an outbreak. Approved drugs are mainly inhibitors of neuraminidase and M2 ion channels, but, due to the variability of influenza viruses, resistance to these drugs may emerge. Botanicals and their extracts have shown unique advantages in influenza treatment and are widely used in clinics across China. However, there are few reviews on the prevention and treatment of influenza with herbal medicines. We undertook a review of relevant literature in recent years to analyze the research progress of various botanicals and their extracts in the prevention and treatment of influenza. Our review provides theoretical support for the prevention and treatment of influenza by plant-based medicines, as well as new ideas for the development of novel low-toxicity and multi-target drugs.

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来源期刊

Bioorganic & Medicinal Chemistry Letters 医学-医药化学

CiteScore

5.70

自引率

3.70%

发文量

463

审稿时长

27 days

期刊介绍： Bioorganic & Medicinal Chemistry Letters presents preliminary experimental or theoretical research results of outstanding significance and timeliness on all aspects of science at the interface of chemistry and biology and on major advances in drug design and development. The journal publishes articles in the form of communications reporting experimental or theoretical results of special interest, and strives to provide maximum dissemination to a large, international audience.