抗葡萄球菌药物对院内表皮葡萄球菌的活性研究。

A Fabbri, A Tacchella, M L Belli
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引用次数: 0

摘要

报告了该院临床分离的72株表皮葡萄球菌对头孢菌素、头孢曼度、fce22101、庆大霉素、奈替米星、阿米卡星、利福平、克林霉素、乔沙霉素、氧氟沙星、环丙沙星、万古霉素和替柯planin的活性,发现耐甲氧西林比例较高(68.05%),同时对庆大霉素(72.22%)、利福平(27.7%)、克林霉素(36.1%)、乔沙霉素(40.27%)等重要药物耐药。他们还记录了所研究的-内酰胺类药物的良好抑制活性。然而,当在特定的技术条件下(高渗培养基,30℃孵育,接种量= 10)进行试验时,对甲氧西林耐药菌株的活性未得到证实。作者还强调了对这些菌株较差的杀菌活性。喹诺酮类药物活性良好;所有菌株对万古霉素和替可普宁的活性都很好。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The activity of antistaphylococcal drugs on nosocomial Staphylococcus epidermidis.

In reporting on the activity of cephalothin, cefamandole, FCE 22101, gentamicin, netilmicin, amikacin, rifampicin, clindamycin, josamycin, ofloxacin, ciprofloxacin, vancomycin and teicoplanin on 72 Staphylococcus epidermidis strains clinically isolated in the hospital, the Authors observed a high percentage of methicillin-resistance (68.05%) as well as resistance to other important drugs such as gentamicin (72.22%), rifampicin (27.7%), clindamycin (36.1%), and josamycin (40.27%). They also recorded good inhibitory activity of the studied beta-lactam drugs. However, this activity was not confirmed against methicillin-resistant strains when the test was performed under particular technical conditions (hypertonic medium, incubation at 30 degrees C, inoculum = 10(6)). The Authors also emphasize the poor bactericidal activity against these strains. The activity of quinolones was good; the activity of vancomycin and teicoplanin was very good on all strains studied.

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