Pathophysiology-Directed Engineering of a Combination Nanoanalgesic for Neuropathic Pain (Adv. Sci. 8/2025)
Combination Nanoanalgesic for Neuropathic Pain
In article number 2405483, Yue Zhou, Jianxiang Zhang, and co-workers report a combination nanoanalgesic composed of inflammation-resolving nanomicelles and an analgesic peptide targeting the calcium channel α2δ1 subunit. This innovative nanotherapy effectively inhibits neuroinflammation, promotes nerve regeneration, and provides analgesic activity, thereby affording synergistic effects for the treatment of neuropathic pain induced by nerve injury.
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