{"title":"双性黄瓜的保肝联苯衍生物","authors":"Qinge Ma, Wenmin Liu, Zhipei Sang, Rongrui Wei","doi":"10.1007/s10600-025-04578-6","DOIUrl":null,"url":null,"abstract":"<p>A new tetraphenylene, named 6-(3′,4′-dihydroxy-5-methyl-[1,1′-biphenyl]-3-yl)-2,5-dihydroxybenzofuran-7-yl 2,4-dihydroxy-3-(3-methylbut-2-en-1-yl)benzoate (<b>1</b>), and seven known biphenyl derivatives (<b>2–8</b>) were isolated from <i>Cucumis bisexualis</i> for the first time. The structures of compounds <b>(1–8</b>) were determined by their spectral data and related references. Compounds (<b>1–8</b>) were evaluated for their hepatoprotective activities against D-galactosamine-induced toxicity in HL-7702 cells, with bicyclol as a positive control. As a result, compounds <b>1</b>, <b>2</b>, and <b>4</b> displayed moderate hepatoprotective activities.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"61 1","pages":"75 - 79"},"PeriodicalIF":0.8000,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Hepatoprotective Biphenyl Derivatives from Cucumis bisexualis\",\"authors\":\"Qinge Ma, Wenmin Liu, Zhipei Sang, Rongrui Wei\",\"doi\":\"10.1007/s10600-025-04578-6\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>A new tetraphenylene, named 6-(3′,4′-dihydroxy-5-methyl-[1,1′-biphenyl]-3-yl)-2,5-dihydroxybenzofuran-7-yl 2,4-dihydroxy-3-(3-methylbut-2-en-1-yl)benzoate (<b>1</b>), and seven known biphenyl derivatives (<b>2–8</b>) were isolated from <i>Cucumis bisexualis</i> for the first time. The structures of compounds <b>(1–8</b>) were determined by their spectral data and related references. Compounds (<b>1–8</b>) were evaluated for their hepatoprotective activities against D-galactosamine-induced toxicity in HL-7702 cells, with bicyclol as a positive control. As a result, compounds <b>1</b>, <b>2</b>, and <b>4</b> displayed moderate hepatoprotective activities.</p>\",\"PeriodicalId\":514,\"journal\":{\"name\":\"Chemistry of Natural Compounds\",\"volume\":\"61 1\",\"pages\":\"75 - 79\"},\"PeriodicalIF\":0.8000,\"publicationDate\":\"2025-02-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Chemistry of Natural Compounds\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s10600-025-04578-6\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"CHEMISTRY, MEDICINAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemistry of Natural Compounds","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s10600-025-04578-6","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
Hepatoprotective Biphenyl Derivatives from Cucumis bisexualis
A new tetraphenylene, named 6-(3′,4′-dihydroxy-5-methyl-[1,1′-biphenyl]-3-yl)-2,5-dihydroxybenzofuran-7-yl 2,4-dihydroxy-3-(3-methylbut-2-en-1-yl)benzoate (1), and seven known biphenyl derivatives (2–8) were isolated from Cucumis bisexualis for the first time. The structures of compounds (1–8) were determined by their spectral data and related references. Compounds (1–8) were evaluated for their hepatoprotective activities against D-galactosamine-induced toxicity in HL-7702 cells, with bicyclol as a positive control. As a result, compounds 1, 2, and 4 displayed moderate hepatoprotective activities.
期刊介绍:
Chemistry of Natural Compounds publishes reviews and general articles about the structure of different classes of natural compounds, the chemical characteristics of botanical families, genus, and species, to establish the comparative laws and connection between physiological activity and the structure of substances.