The Updated Genome Warehouse: Enhancing Data Value, Security, and Usability to Address Data Expansion.

The Genome Warehouse (GWH), accessible at https://ngdc.cncb.ac.cn/gwh, is an extensively-utilized public repository dedicated to the deposition, management, and sharing of genome assembly sequences, annotations, and metadata. This paper highlights noteworthy enhancements to the GWH since the 2021 version, emphasizing substantial advancements in web interfaces for data submission, database functionality updates, and resource integration. Key updates include the reannotation of released prokaryotic genomes, mirroring of genome resources from National Center for Biotechnology Information (NCBI) GenBank and Reference Sequence Database (RefSeq), integration of Poxviridae sequences, implementation of an online batch submission system, enhancements to the quality control system, advanced search capabilities, and the introduction of a controlled-access mechanism for human genome data. These improvements collectively enhance the ease and security of data submission and access as well as genome data value, thereby improving convenience and utility for researchers in the genomics field.