阿尔茨海默病发病机制中的外周和中枢神经免疫机制

IF 14.9 1区医学 Q1 NEUROSCIENCES

Molecular Neurodegeneration Pub Date : 2025-02-21 DOI:10.1186/s13024-025-00812-5

Shuo Zhang, Yue Gao, Yini Zhao, Timothy Y. Huang, Qiuyang Zheng, Xin Wang

{"title":"阿尔茨海默病发病机制中的外周和中枢神经免疫机制","authors":"Shuo Zhang, Yue Gao, Yini Zhao, Timothy Y. Huang, Qiuyang Zheng, Xin Wang","doi":"10.1186/s13024-025-00812-5","DOIUrl":null,"url":null,"abstract":"Alzheimer’s disease (AD) poses a growing global health challenge as populations age. Recent research highlights the crucial role of peripheral immunity in AD pathogenesis. This review explores how blood-brain barrier disruption allows peripheral immune cells to infiltrate the central nervous system (CNS), worsening neuroinflammation and disease progression. We examine recent findings on interactions between peripheral immune cells and CNS-resident microglia, forming a self-perpetuating inflammatory cycle leading to neuronal dysfunction. Moreover, this review emphasizes recent developments in the dysregulation of immune factors from both the periphery and CNS, and their impact on AD progression. With ongoing research and development of new therapeutic strategies, this review underscores the importance of modulating interactions between the peripheral immune system and CNS in AD therapy.","PeriodicalId":18800,"journal":{"name":"Molecular Neurodegeneration","volume":"81 1","pages":""},"PeriodicalIF":14.9000,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Peripheral and central neuroimmune mechanisms in Alzheimer’s disease pathogenesis\",\"authors\":\"Shuo Zhang, Yue Gao, Yini Zhao, Timothy Y. Huang, Qiuyang Zheng, Xin Wang\",\"doi\":\"10.1186/s13024-025-00812-5\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Alzheimer’s disease (AD) poses a growing global health challenge as populations age. Recent research highlights the crucial role of peripheral immunity in AD pathogenesis. This review explores how blood-brain barrier disruption allows peripheral immune cells to infiltrate the central nervous system (CNS), worsening neuroinflammation and disease progression. We examine recent findings on interactions between peripheral immune cells and CNS-resident microglia, forming a self-perpetuating inflammatory cycle leading to neuronal dysfunction. Moreover, this review emphasizes recent developments in the dysregulation of immune factors from both the periphery and CNS, and their impact on AD progression. With ongoing research and development of new therapeutic strategies, this review underscores the importance of modulating interactions between the peripheral immune system and CNS in AD therapy.\",\"PeriodicalId\":18800,\"journal\":{\"name\":\"Molecular Neurodegeneration\",\"volume\":\"81 1\",\"pages\":\"\"},\"PeriodicalIF\":14.9000,\"publicationDate\":\"2025-02-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Molecular Neurodegeneration\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1186/s13024-025-00812-5\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"NEUROSCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Molecular Neurodegeneration","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s13024-025-00812-5","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"NEUROSCIENCES","Score":null,"Total":0}

引用次数: 0

摘要

随着人口老龄化，阿尔茨海默病（AD）对全球健康构成越来越大的挑战。近年来的研究强调了外周免疫在阿尔茨海默病发病中的重要作用。这篇综述探讨了血脑屏障的破坏如何允许外周免疫细胞浸润中枢神经系统（CNS），加剧神经炎症和疾病进展。我们研究了外周免疫细胞和中枢神经系统小胶质细胞之间相互作用的最新发现，形成了一个自我延续的炎症循环，导致神经元功能障碍。此外，本综述强调了外周和中枢神经系统免疫因子失调的最新进展，以及它们对AD进展的影响。随着新的治疗策略的不断研究和发展，本综述强调了调节外周免疫系统和中枢神经系统之间的相互作用在阿尔茨海默病治疗中的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Peripheral and central neuroimmune mechanisms in Alzheimer’s disease pathogenesis

Alzheimer’s disease (AD) poses a growing global health challenge as populations age. Recent research highlights the crucial role of peripheral immunity in AD pathogenesis. This review explores how blood-brain barrier disruption allows peripheral immune cells to infiltrate the central nervous system (CNS), worsening neuroinflammation and disease progression. We examine recent findings on interactions between peripheral immune cells and CNS-resident microglia, forming a self-perpetuating inflammatory cycle leading to neuronal dysfunction. Moreover, this review emphasizes recent developments in the dysregulation of immune factors from both the periphery and CNS, and their impact on AD progression. With ongoing research and development of new therapeutic strategies, this review underscores the importance of modulating interactions between the peripheral immune system and CNS in AD therapy.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Molecular Neurodegeneration 医学-神经科学

CiteScore

23.00

自引率

4.60%

发文量

审稿时长

6-12 weeks

期刊介绍： Molecular Neurodegeneration, an open-access, peer-reviewed journal, comprehensively covers neurodegeneration research at the molecular and cellular levels. Neurodegenerative diseases, such as Alzheimer's, Parkinson's, Huntington's, and prion diseases, fall under its purview. These disorders, often linked to advanced aging and characterized by varying degrees of dementia, pose a significant public health concern with the growing aging population. Recent strides in understanding the molecular and cellular mechanisms of these neurodegenerative disorders offer valuable insights into their pathogenesis.