通过alcl3介导的CN键裂解，乙酰氨基酮与二芳基膦氧化物的相邻二磷酸化

IF 1.5 4区化学 Q3 CHEMISTRY, ORGANIC

Tetrahedron Letters Pub Date : 2025-02-20 DOI:10.1016/j.tetlet.2025.155472

Xin Jin , Yong An , Jia Chen , Xianheng Wang , Huabin Wang , Changkuo Zhao , Qiang Huang

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引用次数: 0

摘要

本研究以AlCl3为路易斯酸，建立了胺酮与二芳基氧化膦相邻二磷酸化的条件。该转化具有良好的官能团耐受性，操作简单，产率高，为获得各种二磷基产物3a提供了一种替代策略。初步机制研究表明，1a和2a之间的转化涉及二甲胺的消除和级联剂的添加。本研究对胺酮的邻域功能化具有重要的研究价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Vicinal diphosphorylation of enaminones with diaryl phosphine oxides via AlCl3-mediated CN bond cleavage

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Vicinal diphosphorylation of enaminones with diaryl phosphine oxides via AlCl3-mediated CN bond cleavage

A vicinal diphosphorylation of enaminones with diaryl phosphine oxides have been established condition through AlCl₃ as Lewis acid in this work. The transformation features excellent functional group tolerance, operational simplicity, and high yields, which provides an alternative strategy for accessing various diphosphoryl products 3a. Preliminary mechanism studies suggest the conversion between 1a and 2a involves the elimination of dimethylamine and cascade vicinal addition. This research provides significant value to the vicinal functionalization of enaminones.

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来源期刊

Tetrahedron Letters 化学-有机化学

CiteScore

3.50

自引率

5.60%

发文量

521

审稿时长

28 days

期刊介绍： Tetrahedron Letters provides maximum dissemination of outstanding developments in organic chemistry. The journal is published weekly and covers developments in techniques, structures, methods and conclusions in experimental and theoretical organic chemistry. Rapid publication of timely and significant research results enables researchers from all over the world to transmit quickly their new contributions to large, international audiences.