人参的抗病毒潜力：用人参提取的化合物靶向人类病原病毒

IF 6.8 2区医学 Q1 CHEMISTRY, MEDICINAL

Journal of Ginseng Research Pub Date : 2024-12-10 DOI:10.1016/j.jgr.2024.12.004

Chen Huo , Jihye Baek , Ki Hyun Kim

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引用次数: 0

摘要

COVID-19大流行凸显了对有效抗病毒治疗的迫切需要，因为病毒感染仍然是全球死亡的主要原因。天然化合物，特别是从植物中提取的化合物，已被公认具有治疗作用。特别是人参，因其潜在的抗病毒作用而引起了相当大的关注。本文综述了人参中抗多种人类病原病毒的抗病毒化合物。我们系统地总结了人参化合物对一系列病毒的抗病毒活性，包括人类鼻病毒（HRV）、流感病毒、人类免疫缺陷病毒（HIV）、肝炎病毒a、B和C （HAV、HBV、HCV）、单纯疱疹病毒（HSV）、肠病毒71 （EV71）、柯萨奇病毒、诺如病毒和导致COVID-19的SARS-CoV-2。本文综述了人参、三七和西洋参的作用机制和治疗潜力。该分析纳入了2002年2月至2024年8月的文献，全面概述了人参中提取的化合物的抗病毒特性的现有证据。本文综述了人参作为抗病毒药物或营养品开发的科学依据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Antiviral potential of ginseng: Targeting human pathogenic viruses with compounds derived from ginseng

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Antiviral potential of ginseng: Targeting human pathogenic viruses with compounds derived from ginseng

The COVID-19 pandemic has highlighted the critical need for effective antiviral therapies, as viral infections remain a leading cause of mortality worldwide. Natural compounds, especially those derived from plants, have been recognized for their therapeutic properties. Ginseng, in particular, has attracted considerable attention for its potential antiviral effects. This review examines the antiviral compounds from ginseng that act against various human pathogenic viruses. We systematically summarize the antiviral activities of ginseng compounds targeting a range of viruses, including human rhinovirus (HRV), influenza virus, human immunodeficiency virus (HIV), hepatitis viruses A, B, and C (HAV, HBV, HCV), herpes simplex virus (HSV), enterovirus 71 (EV71), coxsackievirus, norovirus, and SARS-CoV-2, the virus responsible for COVID-19. This review covers Panax ginseng, P. notoginseng, and P. quinquefolius, discussing their mechanisms of action and therapeutic potential. The analysis incorporates literature from February 2002 through August 2024, providing a comprehensive overview of the existing evidence on the antiviral properties of compounds derived from ginseng. This review aims to underscore the scientific basis for developing ginseng as an antiviral therapeutic agent or nutraceutical.

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来源期刊

Journal of Ginseng Research CHEMISTRY, MEDICINAL-INTEGRATIVE & COMPLEMENTARY MEDICINE

CiteScore

11.40

自引率

9.50%

发文量

111

审稿时长

6-12 weeks

期刊介绍： Journal of Ginseng Research (JGR) is an official, open access journal of the Korean Society of Ginseng and is the only international journal publishing scholarly reports on ginseng research in the world. The journal is a bimonthly peer-reviewed publication featuring high-quality studies related to basic, pre-clinical, and clinical researches on ginseng to reflect recent progresses in ginseng research. JGR publishes papers, either experimental or theoretical, that advance our understanding of ginseng science, including plant sciences, biology, chemistry, pharmacology, toxicology, pharmacokinetics, veterinary medicine, biochemistry, manufacture, and clinical study of ginseng since 1976. It also includes the new paradigm of integrative research, covering alternative medicinal approaches. Article types considered for publication include review articles, original research articles, and brief reports. JGR helps researchers to understand mechanisms for traditional efficacy of ginseng and to put their clinical evidence together. It provides balanced information on basic science and clinical applications to researchers, manufacturers, practitioners, teachers, scholars, and medical doctors.