菊池-藤本病:综合临床病理特征和复发危险因素的研究。

IF 3.9 2区 医学 Q2 CELL BIOLOGY
Histopathology Pub Date : 2025-02-17 DOI:10.1111/his.15427
Midori Filiz Nishimura, Chikako Sakao, Yuka Kurokawa, Yoshito Nishimura, Asami Nishikori, Hidetaka Yamamoto, Yasuharu Sato
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引用次数: 0

摘要

目的:菊池-藤本病(KFD)是一种罕见的疾病,典型表现为发烧和颈部淋巴结病变。对于与复发相关的危险因素及其与临床病理特征的相关性知之甚少。方法和结果:我们分析了112例KFD患者,以女性为主(61/112,54.5%),平均年龄29.4岁。20岁以下的男性发病率较高,30岁以上的女性发病率较高。在随访数据的70例患者中,23%复发。与短暂性疾病相比,复发与较低的C4水平(P = 0.038)和较高的抗核抗体(ANA)率(P = 0.007)相关。平均症状持续时间为71.5天。98例(不包括14例针活检标本)的淋巴结组织学分为三种类型:增生性(n = 75, 77%)、坏死性(n = 22, 22%)和黄瘤性(n = 1.1, 1%)。与增生型相比,坏死性伴淋巴结肿大(P = 0.047),症状持续时间较长(P = 0.009)。结论:低C4水平和ANA阳性与KFD复发相关。短句来源尽管KFD的病因尚不清楚,但考虑到一些病例会发展为自身免疫性疾病,研究结果表明,复发性KFD患者处于一过性KFD和明显自身免疫性疾病之间的中间状态。本研究的综合临床病理结果可能有助于阐明其发病机制和预测临床病程。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Kikuchi-Fujimoto disease: investigating comprehensive clinicopathological features and risk factors for recurrence.

Aims: Kikuchi-Fujimoto disease (KFD) is a rare disease that typically manifests with fever and cervical lymphadenopathy. Little is known about the risk factors associated with recurrence and their correlation with clinicopathologic features.

Methods and results: We analysed 112 patients with KFD, predominantly female (61/112, 54.5%), with an average age of 29.4 years. The incidence was higher in males up to the age of 20 and higher in females from their 30s onwards. Of the 70 patients with follow-up data, 23% experienced recurrence. Recurrence was associated with lower C4 levels (P = 0.038) and higher antinuclear antibody (ANA) rates (P = 0.007) compared to transient disease. The mean duration of symptoms was 71.5 days. Lymph node histology in 98 cases (excluding 14 needle biopsy specimens) was classified into three patterns: proliferative (n = 75, 77%), necrotizing (n = 22, 22%), and xanthomatous (n = 1, 1%). The necrotizing pattern associated with significantly enlarged lymph nodes (P = 0.047) and a longer symptom duration (P = 0.009) than the proliferating pattern. The number of CD4-positive lymphocytes was significantly lower in the necrotizing type than in the proliferative type (P < 0.001).

Conclusion: These results indicated that low C4 levels and positive ANA were associated with KFD recurrence. Although the aetiology of KFD remains elusive, given that some cases develop autoimmune disease, the results suggest that patients with recurrent KFD represent an intermediate status between those with transient KFD and those with overt autoimmune disease. The comprehensive clinicopathological findings of this study may be useful for elucidating its pathogenesis and predicting the clinical course.

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来源期刊
Histopathology
Histopathology 医学-病理学
CiteScore
10.20
自引率
4.70%
发文量
239
审稿时长
1 months
期刊介绍: Histopathology is an international journal intended to be of practical value to surgical and diagnostic histopathologists, and to investigators of human disease who employ histopathological methods. Our primary purpose is to publish advances in pathology, in particular those applicable to clinical practice and contributing to the better understanding of human disease.
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