儿童第三脑室内镜造瘘术后肿瘤内出血一例wnt激活髓母细胞瘤病例报告及文献复习。

IF 1.3 4区 医学 Q4 CLINICAL NEUROLOGY
Pietro Spennato, Massimiliano Porzio, Lucia De Martino, Alessia Imperato, Giulia Meccariello, Giuseppe Cinalli
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引用次数: 0

摘要

瘤内出血是脑脊液(CSF)引流手术(如脑室-腹膜分流术或脑室外引流术)的一种已知并发症,通常与后窝内容物向上突出有关。相比之下,这种情况在内窥镜第三脑室造口术(ETV)后极为罕见。该技术应通过限制幕下腔室和幕上腔室之间的压力梯度,以更生理的方式排出脑脊液,从而避免肿瘤向上突出和肿瘤内出血。文献中仅报道了三例ETV术后肿瘤内出血。我们在此报告一名九岁男童,因后颅窝大肿瘤继发脑积水,经ETV手术后出现肿瘤内出血。他需要紧急血肿清除和肿瘤切除。组织学和分子诊断为wnt激活的髓母细胞瘤,一种与出血风险增加相关的肿瘤。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Intra-tumoral hemorrhage after endoscopic third ventriculostomy in a child with WNT-activated medulloblastoma: case report and literature review.

Intratumoral hemorrhage is a known complication of cerebrospinal fluid (CSF) drainage surgeries, such as ventriculoperitoneal shunts or external ventricular drainage, which are usually associated with upward herniation of the posterior fossa contents. In contrast, this is extremely rare after an endoscopic third ventriculostomy (ETV). This technique should drain the CSF in a more physiological way by limiting the pressure gradient between the infratentorial and supratentorial compartments, thus avoiding upward herniation of the tumor and intratumoral hemorrhage. Only three cases of intratumoral hemorrhage after ETV have been reported in the literature. Here, we describe a 9-year-old boy affected by hydrocephalus secondary to a large posterior fossa tumor who presented intratumoral hemorrhage after ETV. He required urgent hematoma evacuation and tumor removal. Histological and molecular diagnosis was WNT-activated medulloblastoma, a tumor associated with an increased risk of hemorrhage.

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来源期刊
Child's Nervous System
Child's Nervous System 医学-临床神经学
CiteScore
3.00
自引率
7.10%
发文量
322
审稿时长
3 months
期刊介绍: The journal has been expanded to encompass all aspects of pediatric neurosciences concerning the developmental and acquired abnormalities of the nervous system and its coverings, functional disorders, epilepsy, spasticity, basic and clinical neuro-oncology, rehabilitation and trauma. Global pediatric neurosurgery is an additional field of interest that will be considered for publication in the journal.
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