氧吲哚的氧化还原-中性双碳氢官能化构建全碳季中心

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-02-18 DOI:10.1021/acs.orglett.5c00021

Priyankar Jha, Saddam Husen, Ravindra Kumar

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引用次数: 0

摘要

本文报道了用苯胺催化氧化还原-中性双碳氢化合物氧化吲哚的双碳氢官能化反应。反应通过扩展共振稳定碳正离子通过多能四取代烯烃中间体进行。它为氧吲哚周围提供了广阔的化学空间，产生了所有碳季中心（>；35个例子），收率很高。开发过程具有高度的区域选择性和可扩展性，并且条件在本质上是无害的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Building an All Carbon Quaternary Center via Redox-Neutral Geminal Dual C–H Functionalization of Oxindoles

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Building an All Carbon Quaternary Center via Redox-Neutral Geminal Dual C–H Functionalization of Oxindoles

Reported here is a catalytic redox-neutral geminal dual C–H functionalization of oxindoles with two distinct aromatics using anilines. The reaction proceeded through a pluripotent tetra-substituted alkene intermediate via an extended resonance stabilized carbocation. It furnished wide chemical space around oxindoles with the generation of all carbon quaternary centers (>35 examples) in good to excellent yields. The developed process is highly regioselective and scalable, and the conditions are environmentally benign in nature.

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.