精确组合药物递送的点击反应：一般ph响应的可降解骨架多药策略

IF 4.1 2区化学 Q2 POLYMER SCIENCE

Polymer Chemistry Pub Date : 2025-02-21 DOI:10.1039/d4py01390e

Jiali Wang , Yunpeng Luo , Weixun Duan , Daquan Wang , Lingjie Meng

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引用次数: 0

摘要

一种新型的微环境响应药物共递送系统利用酰基炔基-羟基点击聚合将不同的药物分子与羟基结合在一起。这种创新的多药方法可以实现精确的药物移植和选择性肿瘤微环境降解，促进靶向联合治疗。通过成功合成具有肿瘤细胞杀伤潜力和最小正常细胞损伤的双药多肽药物，该方法为个性化、协同治疗策略提供了一个有前途的平台。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

A click-reaction for precise combination drug delivery: a general pH-responsive degradable backboned polyprodrug strategy†

查看原文本刊更多论文

A click-reaction for precise combination drug delivery: a general pH-responsive degradable backboned polyprodrug strategy†

A novel microenvironment-responsive drug co-delivery system leverages acylalkynyl–hydroxyl click polymerization to incorporate diverse drug molecules with hydroxyl groups. This innovative polyprodrug approach enables precise drug grafting and selective tumor microenvironment degradation, facilitating targeted combination therapy. By successfully synthesizing dual-drug polyprodrugs with demonstrated tumor cell-killing potential and minimal normal cell damage, the method provides a promising platform for personalized, synergistic therapeutic strategies.

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来源期刊

Polymer Chemistry POLYMER SCIENCE-

CiteScore

8.60

自引率

8.70%

发文量

535

审稿时长

1.7 months

期刊介绍： Polymer Chemistry welcomes submissions in all areas of polymer science that have a strong focus on macromolecular chemistry. Manuscripts may cover a broad range of fields, yet no direct application focus is required.