有趣的神经周围细胞-他们的起源，结构，功能和病理意义的最新概述。

IF 1.2 4区医学 Q4 DEVELOPMENTAL BIOLOGY

Romanian Journal of Morphology and Embryology Pub Date : 2024-10-01 DOI:10.47162/RJME.65.4.02

Anne Marie Constantin, Adina Bianca Boşca, Carmen Bianca Crivii, Andreea Crintea, Rada Teodora Sufleţel, Bogdan Cătălin Alexandru, Alina Simona Şovrea

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引用次数: 0

摘要

本文概述了独特的复杂和独特的神经周围膜包裹神经纤维束。它由神经周围细胞（PCs）、结缔组织和血管组成。神经周围膜为有效的信号传递创造了微环境，保护和维持神经元的结构和功能，促进神经元的修复。PCs是一种独特类型的肌成纤维细胞，对维持神经稳态至关重要。它们作为有效的血神经屏障（BNB），防止毒素、感染和机械创伤。尽管它们具有至关重要的功能，但pc的起源、超微结构、分子结构和功能作用仍然是一个谜，使它们成为一个迷人的研究领域。

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The intriguing perineurial cells - an updated overview of their origin, structure, functions and implication in pathology.

The paper overviews the uniquely intricate and distinct perineurium that envelops nerve fibers in bundles. It consists of perineurial cells (PCs), connective tissue, and blood vessels. The perineurium creates a microenvironment for efficient signal transmission, protects and maintains neuronal structure and function, and facilitates neuronal repair. PCs are a unique type of myofibroblasts essential for maintaining nerve homeostasis. They act as an effective blood-nerve barrier (BNB), protecting against toxins, infections, and mechanical trauma. Despite their crucial function, the origin, ultrastructure, molecular structure, and functional roles of PCs remain a mystery, making them a fascinating area of study.

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来源期刊

Romanian Journal of Morphology and Embryology DEVELOPMENTAL BIOLOGY-

CiteScore

1.70

自引率

20.00%

发文量

221

审稿时长

3-8 weeks

期刊介绍： Romanian Journal of Morphology and Embryology (Rom J Morphol Embryol) publishes studies on all aspects of normal morphology and human comparative and experimental pathology. The Journal accepts only researches that utilize modern investigation methods (studies of anatomy, pathology, cytopathology, immunohistochemistry, histochemistry, immunology, morphometry, molecular and cellular biology, electronic microscopy, etc.).