结肠癌治疗进展：多西紫杉醇及纳米技术在提高疗效中的作用综述。

IF 1.1 Q4 PHARMACOLOGY & PHARMACY

Current drug safety Pub Date : 2025-02-14 DOI:10.2174/0115748863353992250207115526

Komal, Dinesh Kumar, Sharib Raza Khan, Prabhjot Kaur, Kankan Majumdar, Nabaparna Chakraborty, Amandeep Singh

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引用次数: 0

摘要

多西紫杉醇具有高蛋白结合和p450介导的代谢，这影响了其药代动力学。作为紫杉烷家族的化疗药物，它稳定微管并破坏细胞分裂。多西紫杉醇联合5-氟尿嘧啶和奥沙利铂可提高结肠癌的治疗效果。新兴的药物传递系统，包括纳米颗粒和胶束，旨在提高疗效，同时降低毒性。然而，其在妊娠期间的安全性仍不确定，正在进行的临床试验继续评估其治疗潜力。

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Advancements in Colon Cancer Therapy: A Review on Docetaxel and the Role of Nanotechnology in Enhancing Efficacy.

Docetaxel exhibits high protein binding and P450-mediated metabolism, which influences its pharmacokinetics. As a taxane-family chemotherapeutic agent, it stabilizes microtubules and disrupts cell division. Combining docetaxel with agents like 5-fluorouracil and oxaliplatin enhances treatment outcomes for colon cancer. Emerging drug delivery systems, including nanoparticles and micelles, aim to improve efficacy while reducing toxicity. However, its safety during pregnancy remains uncertain, and ongoing clinical trials continue to evaluate its therapeutic potential.

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来源期刊

Current drug safety PHARMACOLOGY & PHARMACY-

CiteScore

2.10

自引率

0.00%

发文量

112

期刊介绍： Current Drug Safety publishes frontier articles on all the latest advances on drug safety. The journal aims to publish the highest quality research articles, reviews and case reports in the field. Topics covered include: adverse effects of individual drugs and drug classes, management of adverse effects, pharmacovigilance and pharmacoepidemiology of new and existing drugs, post-marketing surveillance. The journal is essential reading for all researchers and clinicians involved in drug safety.