哺乳动物的蛋白质组大小与寿命呈正相关,而鸟类的蛋白质组大小与寿命负相关。

IF 3.2 3区 生物学 Q3 MATERIALS SCIENCE, BIOMATERIALS
Juliano Morimoto, Zuzanna Pietras
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引用次数: 0

摘要

中心法则描述了遗传信息从DNA到蛋白质的单向流动,导致对蛋白质组(生物体中全套蛋白质)中包含的信息的潜力的低估,以反映更广泛的生物过程,如寿命。在这里,通过研究来自四种脊椎动物类的276个蛋白质组的大小和组成与寿命的关系来解决这个问题。在考虑了体重和寿命之间的关系后,鸟类的寿命与蛋白质组大小呈负相关,鱼类的寿命与蛋白质组大小呈弱相关,而哺乳动物的寿命与蛋白质组大小呈正相关。四种脊椎动物的蛋白质组组成各不相同,但没有证据表明任何特定的氨基酸与寿命有关。研究结果与饮食氨基酸限制的作用有关,讨论了寿命延长,并提出了进化和结构力量塑造跨物种蛋白质组组成的问题。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Proteome Size Is Positively Correlated with Lifespan in Mammals but Negatively Correlated with Lifespan in Birds

Proteome Size Is Positively Correlated with Lifespan in Mammals but Negatively Correlated with Lifespan in Birds

The central dogma describes the unidirectional flow of genetic information from DNA to proteins, leading to an underappreciation of the potential for the information contained in proteomes (the full set of proteins in an organism) to reflect broader biological processes such as lifespan. Here, this is addressed by examining how the size and composition of 276 proteomes from four vertebrate classes are related to lifespan. After accounting for the relationship between body weight and lifespan, lifespan is negatively correlated with proteome size in birds and, to a weaker extent, in fish, and positively correlated with lifespan in mammals. Proteome composition varies amongst the four vertebrate classes, but there is no evidence that any specific amino acid correlated with lifespan. The findings in relation to the role of dietary amino acid restriction are discussed on lifespan extension and raise questions about evolutionary and structural forces shaping proteome composition across species.

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来源期刊
Advanced biology
Advanced biology Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)
CiteScore
6.60
自引率
0.00%
发文量
130
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