开心散治疗阿尔茨海默病和抑郁症的研究进展：“以治异”的可能性

Pharmacological Research - Modern Chinese Medicine Pub Date : 2025-02-11 DOI:10.1016/j.prmcm.2025.100589

Chang Liu , Jingji Wang , Guoqi Zhu

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引用次数: 0

摘要

阿尔茨海默病（AD）和抑郁症是两种重要的神经系统疾病，它们有各自的病因和发病机制。现代研究表明，阿尔茨海默病和抑郁症也有一系列共同的病理。此外，阿尔茨海默病和抑郁症往往同时发生，抑郁症出现在阿尔茨海默病的早期，并可加速其发展。因此，AD与抑郁症之间的共同机制值得关注。经典名方开心散（KXS）在临床上可同时治疗阿尔茨海默病和抑郁症。在本研究中，我们回顾了KXS对AD和抑郁症的疗效，并在分析其作用机制的基础上，提出了治疗AD和抑郁症的“同疗法异病”。方法采用scnki数据库、Web of science数据库和PubMed数据库，以“Alzheimer’s disease”、“AD”、“depression”、“Kai-Xin-San”等关键词，对KXS治疗AD和抑郁症的疗效进行分析。结果表明KXS对AD和抑郁症有确切的治疗作用，其机制涉及突触功能、炎症反应、氧化应激、肠道菌群和海马神经发生的调节。根据AD和抑郁症的共同机制，以及KXS的潜在治疗作用，我们提出KXS治疗AD和抑郁症的“同种疗法”疗效。结论综述了AD与抑郁的共同机制，为KXS在神经系统疾病治疗中的应用提供了重要见解。

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Progress of Kai-Xin-San in treating AD and depression: The possibility of "Homotherapy for Heteropathy"

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Progress of Kai-Xin-San in treating AD and depression: The possibility of "Homotherapy for Heteropathy"

Introduction

Alzheimer's disease (AD) and depression are two important neurological disorders with their own causes and pathogenesis. Modern research shows that AD and depression also have a series of common pathologies. Moreover, AD and depression often occur simultaneously, and depression appears in the early stages of AD and can accelerate its progression. Therefore, the common mechanism between AD and depression deserves attention. The classic famous prescription, Kai-Xin-San (KXS) could treat both of AD and depression clinically. In this study, we reviewed the efficacy of KXS against AD and depression, and proposed "Homotherapy for Heteropathy" in treating AD and depression based on the analysis of the mechanisms.

Methods

CNKI database, Web of science database and PubMed database were used to explore the therapeutic effects of KXS on AD and depression with keywords such as “Alzheimer's disease”, “AD”, “depression” and “Kai-Xin-San”, etc.

Results

This review suggests that KXS has exact effects on AD and depression and the mechanisms involve modulations of synaptic function, inflammatory response, oxidative stress, gut microbiota and hippocampal neurogenesis. According to the common mechanisms of AD and depression, and the potential treatment of KXS, we propose the "Homotherapy for Heteropathy" efficacy of KXS in treating AD and depression.

Conclusions

This review summarizes the common mechanisms between AD and depression, providing important insights for the use of KXS in treating neurological diseases.

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来源期刊

Pharmacological Research - Modern Chinese Medicine

CiteScore

1.60

自引率

0.00%

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