miRNA-30c-5p、miRNA-545-3p和miRNA-125a-5p在女性多囊卵巢综合征中的可能调控作用：病例对照研究和信号通路

IF 3.8 3区医学 Q2 CELL BIOLOGY

Molecular and Cellular Endocrinology Pub Date : 2025-02-12 DOI:10.1016/j.mce.2025.112492

Jessica D. Pereira , Fernanda M.V. Magalhães , Fabiana M.S. Tameirão , Frederico M. Soriani , Karina T. de O. S. Jorge , Fernando M. Reis , Ana Lúcia Cândido , Fábio V. Comim , Karina B. Gomes

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引用次数: 0

摘要

多囊卵巢综合征（PCOS）是育龄妇女最常见的内分泌疾病之一。MicroRNA （mirna）是生物体液中与基因表达控制有关的小的非编码rna。我们的研究分析了PCOS患者与对照组相比与炎症相关的mirna的表达。方法选取体重指数和年龄相匹配的PCOS患者20例，对照组20例。评估的mirna为miRNA-30c-5p；miRNA-545-3p和miRNA-125a-5p。结果两组间mirna表达相似。仅在PCOS组中，miRNA-125a-5p的表达与ldl水平呈正相关。随后的生物学通路分析表明，miRNA-125a -5p显著参与胆固醇生物合成、糖酵解、胰岛素受体信号、氧化应激诱导衰老和雌激素依赖基因表达的SREBP/SREBF通路的调控。结论miRNA-125a-5p可能参与PCOS女性脂质生物合成和LDL-c水平的调节。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

The possible regulatory role of miRNA-30c-5p, miRNA-545-3p and miRNA-125a-5p in women with polycystic ovary syndrome: A case-control study and signaling pathways

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The possible regulatory role of miRNA-30c-5p, miRNA-545-3p and miRNA-125a-5p in women with polycystic ovary syndrome: A case-control study and signaling pathways

Introduction

Polycystic Ovary Syndrome (PCOS) is one of the most common endocrinopathy in women of reproductive age. MicroRNA (miRNAs) are small non-coding RNAs related to the control of gene expression in biological fluids. Our study analyzed the expression of miRNAs related to inflammation in individuals with PCOS compared to controls.

Methods

Twenty patients with PCOS and 20 controls, matched by body mass index and age, were included in the study. The miRNAs evaluated were miRNA-30c-5p; miRNA-545-3p and miRNA-125a-5p.

Results

The expression of the miRNAs was similar between the two groups. A positive correlation was observed between the expression of miRNA-125a-5p and LDLc levels only in the PCOS group. Subsequent analysis of biological pathways showed that miRNA-125a -5p is significantly involved in the regulation of SREBP/SREBF pathways of cholesterol biosynthesis, glycolysis, insulin receptor signaling, oxidative stress-induced senescence and estrogen-dependent gene expression.

Conclusion

The results suggest that the miRNA-125a-5p shows a potential implication to the regulation of lipid biosynthesis and LDL-c levels in PCOS women.

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来源期刊

Molecular and Cellular Endocrinology 医学-内分泌学与代谢

CiteScore

9.00

自引率

2.40%

发文量

174

审稿时长

42 days

期刊介绍： Molecular and Cellular Endocrinology was established in 1974 to meet the demand for integrated publication on all aspects related to the genetic and biochemical effects, synthesis and secretions of extracellular signals (hormones, neurotransmitters, etc.) and to the understanding of cellular regulatory mechanisms involved in hormonal control.