UiO-66（Ce）抗癌体系的制备、涂层及多模态治疗性能研究

IF 4.7 2区化学 Q1 CHEMISTRY, INORGANIC & NUCLEAR

Inorganic Chemistry Pub Date : 2025-01-31 DOI:10.1021/acs.inorgchem.4c0478310.1021/acs.inorgchem.4c04783

Quan Hu*, Chen Lei, Yue Sun, Lu Hong, Yu Shi, Liyuan Sang, Bing Wang, Yong Guo* and Wenxin Lin*,

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引用次数: 0

摘要

以金属铈为原料制备了UiO-66(Ce)，可引发类芬顿反应。通过在DOX@UiO-66（Ce）表面包覆金属多酚层（TA-Fe）构建了DOX@UiO-66(Ce)@TA-Fe体系，该体系负载抗癌药物盐酸多柔比星（DOX）。它可以产生活性氧来实现化学动力治疗，并表现出刺激反应性的药物释放行为来实现化疗。此外，该系统显示出对正常细胞（L929细胞）的生物相容性和对癌细胞（MCF-7细胞）的毒性，这意味着多模式癌症治疗的理想效果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Preparation, Coating, and Multimodal Therapeutic Properties of an Anticancer System Based on UiO-66(Ce)

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Preparation, Coating, and Multimodal Therapeutic Properties of an Anticancer System Based on UiO-66(Ce)

UiO-66(Ce) was prepared from cerium metal, which could trigger Fenton-like reactions. A system DOX@UiO-66(Ce)@TA-Fe was constructed by coating a metal polyphenol layer (TA-Fe) on the surface of DOX@UiO-66(Ce), which was loaded with the anticancer drug doxorubicin hydrochloride (DOX). It could produce reactive oxygen species to realize chemodynamic therapy and show stimuli-responsive drug release behaviors to realize chemotherapy. In addition, the system displayed biocompatibility to normal cells (L929 cells) and toxicity to cancer cells (MCF-7 cells), implying an ideal effect for multimodal cancer therapy.

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来源期刊

Inorganic Chemistry 化学-无机化学与核化学

CiteScore

7.60

自引率

13.00%

发文量

1960

审稿时长

1.9 months

期刊介绍： Inorganic Chemistry publishes fundamental studies in all phases of inorganic chemistry. Coverage includes experimental and theoretical reports on quantitative studies of structure and thermodynamics, kinetics, mechanisms of inorganic reactions, bioinorganic chemistry, and relevant aspects of organometallic chemistry, solid-state phenomena, and chemical bonding theory. Emphasis is placed on the synthesis, structure, thermodynamics, reactivity, spectroscopy, and bonding properties of significant new and known compounds.