钯催化邻磺酰胺三氟苯乙酮和2- en -4-羰基酯的发散合成

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-02-15 DOI:10.1021/acs.orglett.5c00269

Meng-Qi Gan, Jian-Xiang Zhu, Zhi-Chao Chen, Wei Du, Ying-Chun Chen

引用次数: 0

摘要

在这里，我们提出了钯催化的邻磺酰胺三氟苯乙酮和2-烯-4-羰基酯之间的发散转化反应。通过调整钯源，从5-芳基取代的碳酸盐中获得了含有(Z)-或(E)-外环双键的富含对映体的2,5-二氢呋喃融合的四氢喹啉，具有中等至高的对映选择性，而用5-烷基取代的化合物则提供了类似的2,3-二氢呋喃融合的产物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Palladium-Catalyzed Divergent Synthesis from o-Sulfonamido Trifluoroacetophenones and 2-En-4-ynyl Carbonates

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Palladium-Catalyzed Divergent Synthesis from o-Sulfonamido Trifluoroacetophenones and 2-En-4-ynyl Carbonates

Here we present a palladium-catalyzed divergent transformative reaction between o-sulfonamido trifluoroacetophenones and 2-en-4-ynyl carbonates. A spectrum of enantioenriched 2,5-dihydrofuran-fused tetrahydroquinolines bearing either a (Z)- or (E)-exocyclic double bond are constructed with moderate to high enantioselectivity from 5-aryl-substituted carbonates by tuning palladium sources, while analogous 2,3-dihydrofuran-fused products are furnished by using 5-alkyl-substituted ones.

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.