秋水仙碱衍生物的最新进展：探索合成、活性和纳米配方以增强治疗效果。

IF 6.5 2区医学 Q1 PHARMACOLOGY & PHARMACY

Drug Discovery Today Pub Date : 2025-02-11 DOI:10.1016/j.drudis.2025.104312

Marialucia Rubicondo , Gianluca Ciardelli , Clara Mattu , Jack A. Tuszynski

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引用次数: 0

摘要

秋水仙碱多方面的抗癌特性使其成为肿瘤治疗的有希望的候选者。然而，其应用受到溶解度差、生物利用度低和全身毒性的限制。为了克服这些挑战，秋水仙碱衍生物和纳米制剂的开发已经付出了相当大的努力。在这篇综述中，我们提供了秋水仙碱衍生物和纳米制剂用于癌症治疗的最新进展的全面概述。对所综述的衍生物和制剂的合成方法和体外抗增殖试验进行了探讨。本文还讨论了诸如耐药性和配方优化等挑战，以及利用秋水仙碱衍生物及其纳米制剂作为创新抗癌策略的全部潜力，走向成功临床应用的未来前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Recent advancements in colchicine derivatives: Exploring synthesis, activities, and nanoformulations for enhanced therapeutic efficacy

The multifaceted anti-cancer properties of colchicine make it a promising candidate for tumor treatment. However, its application has been limited by poor solubility, low bioavailability, and systemic toxicity. Considerable efforts have been directed toward the development of colchicine derivatives and nanoformulations to overcome these challenges. In this review, we provide a comprehensive overview of recent advances in colchicine derivatives and nanoformulations for cancer treatment. Synthesis methods and in vitro antiproliferative assays for the reviewed derivatives and formulations are explored. Challenges, such as drug resistance and formulation optimization, are also addressed, along with future perspectives for leveraging the full potential of colchicine derivatives and their nanoformulations as innovative anti-cancer strategies, toward successful clinical applications.

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来源期刊

Drug Discovery Today 医学-药学

CiteScore

14.80

自引率

2.70%

发文量

293

审稿时长

6 months

期刊介绍： Drug Discovery Today delivers informed and highly current reviews for the discovery community. The magazine addresses not only the rapid scientific developments in drug discovery associated technologies but also the management, commercial and regulatory issues that increasingly play a part in how R&D is planned, structured and executed. Features include comment by international experts, news and analysis of important developments, reviews of key scientific and strategic issues, overviews of recent progress in specific therapeutic areas and conference reports.