新型小瓶内表面处理技术提高化学耐久性和小瓶内表面均匀性,减少药物在小瓶上的吸附。

IF 1.5 4区 医学 Q4 CHEMISTRY, MEDICINAL
Norikazu Miyamoto, Kenta Ohsugi, Taishi Higashi, Keiichi Motoyama
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引用次数: 0

摘要

制药工业在很大程度上依赖于安全有效的药品包装,注射玻璃瓶在这方面起着关键作用。确保这些小瓶的质量和一致性对于保障药物制剂的效力至关重要。在本研究中,通过实施先进的表面处理技术,研究了最近在注射玻璃小瓶制造方面取得的突破。我们开发了潜在的注射玻璃小瓶,使用新的小瓶-内表面处理(VIST)技术来均匀小瓶的内表面。与普通小瓶相比,由于VIST技术,这些注射玻璃小瓶的碱含量和电导率降低,形成了光滑均匀的内表面。此外,药物在VIST小瓶内表面的吸附比在普通小瓶上的吸附明显降低。这些结果表明,VIST瓶质量优良,可作为标准的注射玻璃瓶。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Novel Vial-Inner-Surface Treatment Technology Improves Chemical Durability and Vial-Inner-Surface Uniformity to Reduce Drug Adsorption on the Vial.

The pharmaceutical industry relies heavily on the safe and efficient packaging of drugs and injection glass vials play a pivotal role in this regard. Ensuring the quality and consistency of these vials is essential for safeguarding the potency of pharmaceutical formulations. In this study, the recent breakthroughs achieved in the manufacturing of injection glass vials by implementing advanced surface-processing technologies were examined. We developed potential injection glass vials using the novel vial-inner-surface treatment (VIST) technology to homogenize the inner surface of the vials. Compared with common vials, the elution of alkali contents and conductivity of these injection glass vials were reduced because of the VIST technology, resulting in the formation of smooth and homogeneous inner surfaces. In addition, drug adsorption onto the inner surface of the VIST vials was considerably lowered than that onto common vials. These results suggest that VIST vials are of excellent quality and could become the standard injection glass vials.

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来源期刊
CiteScore
3.20
自引率
5.90%
发文量
132
审稿时长
1.7 months
期刊介绍: The CPB covers various chemical topics in the pharmaceutical and health sciences fields dealing with biologically active compounds, natural products, and medicines, while BPB deals with a wide range of biological topics in the pharmaceutical and health sciences fields including scientific research from basic to clinical studies. For details of their respective scopes, please refer to the submission topic categories below. Topics: Organic chemistry In silico science Inorganic chemistry Pharmacognosy Health statistics Forensic science Biochemistry Pharmacology Pharmaceutical care and science Medicinal chemistry Analytical chemistry Physical pharmacy Natural product chemistry Toxicology Environmental science Molecular and cellular biology Biopharmacy and pharmacokinetics Pharmaceutical education Chemical biology Physical chemistry Pharmaceutical engineering Epidemiology Hygiene Regulatory science Immunology and microbiology Clinical pharmacy Miscellaneous.
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