巴利替尼与β-环糊精及其二聚氨基衍生物的复合物

IF 0.7 4区化学 Q4 CHEMISTRY, PHYSICAL

Russian Journal of Physical Chemistry A Pub Date : 2025-02-11 DOI:10.1134/S0036024424703084

A. A. Garibyan, G. I. Kurochkina, N. V. Kutyasheva, M. K. Grachev, I. V. Terekhova

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引用次数: 0

摘要

本研究比较研究了β-环糊精及其新型二聚二脒衍生物与新一代免疫调节剂巴利替尼的络合和增溶能力。等温饱和度用于测定巴利昔替尼在磷酸盐缓冲溶液（pH 值为 6.8）中存在所考虑的 β-环糊精时的溶解度。计算了复合物形成的热力学参数，并根据 1H NMR 数据提出了一种结合模式。分析了β-环糊精的结构对巴利昔替尼形成络合物和溶解效率的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Complexation of Baricitinib with β-Cyclodextrin and Its Dimeric Amino-Derivatives

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Complexation of Baricitinib with β-Cyclodextrin and Its Dimeric Amino-Derivatives

A comparative study of the complexing and solubilizing capacity of β-cyclodextrin and its new dimeric diaminocationic derivatives in relation to baricitinib, a new generation immunomodulator, is performed. Isothermal saturation is used to determine the solubility of baricitinib in the presence of the considered β‑cyclodextrins in a phosphate buffer solution (pH 6.8). Thermodynamic parameters of complex formation are calculated, and a binding mode is proposed on the basis of ¹H NMR data. The effect of the structure of β-cyclodextrin on the efficiency of complex formation and the solubilization of baricitinib is analyzed.

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来源期刊

Russian Journal of Physical Chemistry A 化学-物理化学

CiteScore

1.20

自引率

14.30%

发文量

376

审稿时长

5.1 months

期刊介绍： Russian Journal of Physical Chemistry A. Focus on Chemistry (Zhurnal Fizicheskoi Khimii), founded in 1930, offers a comprehensive review of theoretical and experimental research from the Russian Academy of Sciences, leading research and academic centers from Russia and from all over the world. Articles are devoted to chemical thermodynamics and thermochemistry, biophysical chemistry, photochemistry and magnetochemistry, materials structure, quantum chemistry, physical chemistry of nanomaterials and solutions, surface phenomena and adsorption, and methods and techniques of physicochemical studies.