硝酸盐和no供体经皮治疗勃起功能障碍的应用综述。

IF 3.6 2区 医学 Q1 UROLOGY & NEPHROLOGY
Fatemeh Khorasanian, Maryam Shami, Mohammad Amin Langarizadeh, Marziye Ranjbar Tavakoli, Hojjat Rezaiezadeh, Hamid Forootanfar
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引用次数: 0

摘要

简介:勃起功能障碍(ED)是影响全球男性最普遍的泌尿系统问题之一,发病率很高。它显著影响患者及其性伴侣的生活质量。目的:鉴于近年来ED在男性中的患病率不断上升,许多药物疗法已经开发出来解决这些问题。然而,ED的全身药物治疗通常伴随着重大挑战,包括药物相互作用和各种医疗条件下的禁忌症。这促使研究人员专注于设计药物和剂型,在保持疗效的同时减少副作用、相互作用和禁忌症。方法:在以往研究的基础上,本文研究了硝酸盐和no供体,重点研究了它们的透皮影响、提高治疗效率的策略、潜在的局部副作用以及各种配方的评估。结果:在这方面,有机硝酸盐如硝酸甘油和硝酸异山梨酯和一氧化氮供体包括挥发性烷基亚硝酸盐、林西多明、硝普钠和l -精氨酸是ED透皮治疗的良好候选者。在这篇文章中,这些化合物的局部作用,无论是单独使用还是与其他药物联合使用,都进行了彻底的研究,包括它们的作用机制、有效性、副作用和禁忌症。结论:基于这些发现,似乎具有增强这些化合物吸收的新配方可以在ED治疗中发挥重要作用,无论是作为单独治疗还是作为辅助治疗。目前,大部分数据来自临床前研究,未来的临床研究可以揭示此类透皮制剂的确切疗效。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Application of nitrates and NO-donors as a transdermal therapy for erectile dysfunction: a comprehensive review.

Introduction: Erectile dysfunction (ED) is among the most prevalent urologic issues affecting men globally, with a notably high incidence rate. It significantly impacts the quality of life of patients and their sexual partners.

Objectives: Given the increasing prevalence of ED among men in recent years, numerous pharmacotherapies have been developed to address these conditions. However, systemic drug therapies for ED are often associated with significant challenges, including drug interactions and contraindications across a wide range of medical conditions. This has prompted researchers to focus on designing drugs and dosage forms that maintain efficacy while reducing side effects, interactions, and contraindications.

Methods: Building on previous studies, this article investigates nitrates and NO-donors with a focus on their transdermal impact, strategies for enhancing therapeutic efficiency, potential local side effects, and the evaluation of various formulations.

Results: In this regard, organic nitrates such as nitroglycerin and isosorbide dinitrate and NO donors comprising volatile alkyl nitrites, linsidomine, sodium nitroprusside, and L-arginine are among good candidates for transdermal formulations of ED treatment. In the current article, the topical effects of these compounds, both alone and in combination with other drugs, have been thoroughly examined, including aspects such as their mechanism of action, effectiveness, side effects, and contraindications.

Conclusion: Based on these findings, it appears that novel formulations with enhanced absorption of these compounds could play a significant role in the treatment of ED, either as a standalone therapy or as an adjunctive treatment. Currently, most of the data are from preclinical studies and future clinical research can reveal the precise efficacy of such transdermal formulations.

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来源期刊
Sexual medicine reviews
Sexual medicine reviews UROLOGY & NEPHROLOGY-
CiteScore
7.60
自引率
8.30%
发文量
5
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