芍药根中两个新化合物的研究。以及它们的抗炎作用。

IF 1.6 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research Pub Date : 2025-02-08 DOI:10.1080/14786419.2025.2462114

Bo Fu, Jin-Ling Zhang, Jia-Tong Wu, Si-Yi Wang, Yi-Qiang Zhang, Juan Pan, Wei Guan, Zhi-Chao Hao, Hai-Xue Kuang, Qing-Shan Chen, Li-Li Zhang, Bing-You Yang, Yan Liu

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引用次数: 0

摘要

从芍药根中分离得到2个新化合物（1-2）和6个已知化合物（3-8）。两个新化合物的结构通过HR-ESI-MS、UV和NMR数据分析得到。此外，利用lps诱导的RAW 264.7细胞检测化合物1-8的抗炎活性。化合物2、6、8对NO的抑制作用最强，IC50值分别为17.34±1.5 μM、27.22±1.3 μM和14.79±1.7 μM。化合物4和7具有中等抑制活性。化合物3和5表现出较弱的抑制活性。

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Two new compounds from the roots of Paeonia lactiflora Pall. and their anti-inflammatory effects.

Two new compounds (1-2), together with six known ones (3-8), were isolated from the roots of Paeonia lactiflora Pall. The structures of two new compounds were elucidated based on HR-ESI-MS, UV, and NMR spectroscopic data analysis. Moreover, the anti-inflammatory activities of compounds 1-8 were determined using LPS-induced RAW 264.7 cells. Compounds 2, 6, and 8 showed the most potent inhibitory activities on NO production with IC₅₀ values of 17.34 ± 1.5, 27.22 ± 1.3, and 14.79 ± 1.7 μM, respectively. Compounds 4 and 7 showed moderate inhibitory activities. Compounds 3 and 5 showed relatively weak inhibitory activities.

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.