脑缺血机制和治疗方法的进展：最近的见解和炎症驱动的风险。

IF 4.6 2区医学 Q1 NEUROSCIENCES

Experimental Neurology Pub Date : 2025-02-06 DOI:10.1016/j.expneurol.2025.115177

Doyoon Kim , Satoru Morikawa , Taneaki Nakagawa , Hideyuki Okano , Yoshitaka Kase

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引用次数: 0

摘要

现有的脑卒中根治性治疗的应用仅限于少数病例，目前的实践主要集中于保守治疗。本文综述了脑卒中引起的脑缺血期间的兴奋毒性、氧化应激和炎症的病理生理学，重点介绍了每种病理的见解，并报告了有望作为新治疗选择的最新治疗进展。最后，我们概述了最近对牙周病和中风之间关系的关注。我们建议解决现有中风治疗方法的局限性，并提出新的治疗方法，同时也提出牙周病治疗对中风预防的潜在贡献。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Advances in brain ischemia mechanisms and treatment approaches: Recent insights and inflammation-driven risks

查看原文本刊更多论文

Advances in brain ischemia mechanisms and treatment approaches: Recent insights and inflammation-driven risks

The application of existing radical treatments for stroke is limited to a small number of cases, with current practices predominantly focusing on conservative therapy. This review examines the pathophysiology of excitotoxicity, oxidative stress, and inflammation during brain ischemia caused by stroke, highlighting insights into each pathology and reporting the latest therapeutic developments that are expected to serve as new treatment options. Finally, we outline the recent attention given to the relationship between periodontal disease and stroke. We propose addressing the limitations of existing treatments for stroke and suggest novel therapeutic approaches while also presenting the potential contribution of periodontal disease treatment to the prevention of stroke.

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来源期刊

Experimental Neurology 医学-神经科学

CiteScore

10.10

自引率

3.80%

发文量

258

审稿时长

42 days

期刊介绍： Experimental Neurology, a Journal of Neuroscience Research, publishes original research in neuroscience with a particular emphasis on novel findings in neural development, regeneration, plasticity and transplantation. The journal has focused on research concerning basic mechanisms underlying neurological disorders.