n -卤代琥珀酰亚胺（NXS）在芳香化合物亲电卤化反应中的研究进展

IF 1.5 4区化学 Q3 CHEMISTRY, ORGANIC

Tetrahedron Letters Pub Date : 2025-01-30 DOI:10.1016/j.tetlet.2024.155419

Kiyoshi Tanemura

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引用次数: 0

摘要

芳香化合物的卤化反应是现代合成化学中最重要的反应之一。芳香族卤化物是金属催化交叉偶联反应、取代反应以及制备药物和天然产物的重要合成中间体。人们一直致力于芳基卤化物的合成。本文综述了近6年来Brønsted/Lewis酸或Lewis碱催化n -卤代琥珀酰亚胺（NXS）卤化芳香族化合物的研究进展。它特别关注底物范围，反应机制和未来的挑战。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Recent advances in the electrophilic halogenation of aromatic compounds using N-halosuccinimides (NXS)

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Recent advances in the electrophilic halogenation of aromatic compounds using N-halosuccinimides (NXS)

Halogenation of aromatic compounds is one of the most crucial reactions in modern synthetic chemistry. Aromatic halides are important synthetic intermediates used in metal-catalyzed cross-coupling reactions, substitution reactions, and the preparation of drugs and natural products. Continuous efforts have been devoted to the synthesis of aryl halides. This review summarizes the recent progress in the Brønsted/Lewis acid or Lewis base-catalyzed halogenation of aromatic compounds using N-halosuccinimides (NXS) over the past six years. In particular, it focuses on substrate scope, reaction mechanisms, and future challenges.

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来源期刊

Tetrahedron Letters 化学-有机化学

CiteScore

3.50

自引率

5.60%

发文量

521

审稿时长

28 days

期刊介绍： Tetrahedron Letters provides maximum dissemination of outstanding developments in organic chemistry. The journal is published weekly and covers developments in techniques, structures, methods and conclusions in experimental and theoretical organic chemistry. Rapid publication of timely and significant research results enables researchers from all over the world to transmit quickly their new contributions to large, international audiences.