总状无花果果实甲醇提取物的化学成分及药理活性研究

Harshvardhan Pant , Sandeep Negi , Kumud Saklani , Subhash Chandra , Lucia Raquel de Lima , Henrique Douglas Melo Coutinho
{"title":"总状无花果果实甲醇提取物的化学成分及药理活性研究","authors":"Harshvardhan Pant ,&nbsp;Sandeep Negi ,&nbsp;Kumud Saklani ,&nbsp;Subhash Chandra ,&nbsp;Lucia Raquel de Lima ,&nbsp;Henrique Douglas Melo Coutinho","doi":"10.1016/j.prenap.2025.100163","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div><em>Ficus racemosa</em> Linn is a well-known medicinal plant in various traditional systems of medicine and is used to treat kidney stones, biliary disorders, jaundice, diarrhea, inflammatory conditions, liver disorders, hemorrhoids, respiratory and urinary diseases. We investigated the <em>in vitro and in vivo</em> antidiabetic activity, antimicrobial activity, and nutritional profile of the fruit methanolic extract of <em>F. racemosa</em>.</div></div><div><h3>Methods</h3><div>Applying the alpha (α)-amylase and alpha (α)-glucosidase enzymes and disc diffusion methods. Strong antidiabetic effects were seen <em>in vitro</em> and <em>in vivo</em> in the methanolic extract of the fruit portion of <em>F. racemosa</em>.</div></div><div><h3>Results</h3><div>The methanolic extract reduced blood glucose levels to the greatest extent (31.20% <em>in vivo</em> and 68.10% <em>in vitro</em>). The methanolic extract demonstrated potent activity at 16<!--> <!-->mm and 15<!--> <!-->mm against <em>Staphylococcus</em> and <em>Bacillus ceresus</em> with the disc diffusion method.</div></div><div><h3>Conclusions</h3><div>The methanolic crude extracts exhibit strong antidiabetic and antimicrobial activity, especially against <em>Staphylococcus</em> and <em>Bacillus ceresus.</em> Nutrients represent their potent pharmacological applications. The presence of secondary metabolites (flavonoids, alkaloids, phenolics, saponins, and terpenoids) in the crude methanolic extract may cause its antidiabetic and antimicrobial properties.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"6 ","pages":"Article 100163"},"PeriodicalIF":0.0000,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"CHEMICAL COMPOSITION AND PHARMACOLOGICAL ACTIVITIES OF FICUS RACEMOSA FRUIT METHANOLIC EXTRACT\",\"authors\":\"Harshvardhan Pant ,&nbsp;Sandeep Negi ,&nbsp;Kumud Saklani ,&nbsp;Subhash Chandra ,&nbsp;Lucia Raquel de Lima ,&nbsp;Henrique Douglas Melo Coutinho\",\"doi\":\"10.1016/j.prenap.2025.100163\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><div><em>Ficus racemosa</em> Linn is a well-known medicinal plant in various traditional systems of medicine and is used to treat kidney stones, biliary disorders, jaundice, diarrhea, inflammatory conditions, liver disorders, hemorrhoids, respiratory and urinary diseases. We investigated the <em>in vitro and in vivo</em> antidiabetic activity, antimicrobial activity, and nutritional profile of the fruit methanolic extract of <em>F. racemosa</em>.</div></div><div><h3>Methods</h3><div>Applying the alpha (α)-amylase and alpha (α)-glucosidase enzymes and disc diffusion methods. Strong antidiabetic effects were seen <em>in vitro</em> and <em>in vivo</em> in the methanolic extract of the fruit portion of <em>F. racemosa</em>.</div></div><div><h3>Results</h3><div>The methanolic extract reduced blood glucose levels to the greatest extent (31.20% <em>in vivo</em> and 68.10% <em>in vitro</em>). The methanolic extract demonstrated potent activity at 16<!--> <!-->mm and 15<!--> <!-->mm against <em>Staphylococcus</em> and <em>Bacillus ceresus</em> with the disc diffusion method.</div></div><div><h3>Conclusions</h3><div>The methanolic crude extracts exhibit strong antidiabetic and antimicrobial activity, especially against <em>Staphylococcus</em> and <em>Bacillus ceresus.</em> Nutrients represent their potent pharmacological applications. The presence of secondary metabolites (flavonoids, alkaloids, phenolics, saponins, and terpenoids) in the crude methanolic extract may cause its antidiabetic and antimicrobial properties.</div></div>\",\"PeriodicalId\":101014,\"journal\":{\"name\":\"Pharmacological Research - Natural Products\",\"volume\":\"6 \",\"pages\":\"Article 100163\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-02-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pharmacological Research - Natural Products\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2950199725000230\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pharmacological Research - Natural Products","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2950199725000230","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

总形榕树(ficus racemosa Linn)是一种在各种传统医学体系中众所周知的药用植物,用于治疗肾结石、胆道疾病、黄疸、腹泻、炎症、肝脏疾病、痔疮、呼吸和泌尿系统疾病。研究了总状花果甲醇提取物的体内外抗糖尿病活性、抗菌活性和营养成分。方法采用α (α)-淀粉酶法和α (α)-葡萄糖苷酶法及圆盘扩散法。总状花果部甲醇提取物在体内和体外均有较强的抗糖尿病作用。结果甲醇提取物对大鼠血糖的降低作用最大,体内降低31.20%,体外降低68.10%。用圆盘扩散法对乙醇提取物在16 mm和15 mm处对葡萄球菌和蜡样芽孢杆菌有较强的活性。结论甲醇粗提物具有较强的抗糖尿病和抗菌活性,对葡萄球菌和啤酒芽孢杆菌具有较强的抑制作用。营养素代表了它们强有力的药理学应用。粗甲醇提取物中次生代谢物(黄酮类、生物碱、酚类、皂苷和萜类)的存在可能导致其抗糖尿病和抗菌特性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
CHEMICAL COMPOSITION AND PHARMACOLOGICAL ACTIVITIES OF FICUS RACEMOSA FRUIT METHANOLIC EXTRACT

Background

Ficus racemosa Linn is a well-known medicinal plant in various traditional systems of medicine and is used to treat kidney stones, biliary disorders, jaundice, diarrhea, inflammatory conditions, liver disorders, hemorrhoids, respiratory and urinary diseases. We investigated the in vitro and in vivo antidiabetic activity, antimicrobial activity, and nutritional profile of the fruit methanolic extract of F. racemosa.

Methods

Applying the alpha (α)-amylase and alpha (α)-glucosidase enzymes and disc diffusion methods. Strong antidiabetic effects were seen in vitro and in vivo in the methanolic extract of the fruit portion of F. racemosa.

Results

The methanolic extract reduced blood glucose levels to the greatest extent (31.20% in vivo and 68.10% in vitro). The methanolic extract demonstrated potent activity at 16 mm and 15 mm against Staphylococcus and Bacillus ceresus with the disc diffusion method.

Conclusions

The methanolic crude extracts exhibit strong antidiabetic and antimicrobial activity, especially against Staphylococcus and Bacillus ceresus. Nutrients represent their potent pharmacological applications. The presence of secondary metabolites (flavonoids, alkaloids, phenolics, saponins, and terpenoids) in the crude methanolic extract may cause its antidiabetic and antimicrobial properties.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信