细胞衰老与PAPP-A

IF 1.6 4区医学 Q4 CELL BIOLOGY

Growth Hormone & Igf Research Pub Date : 2025-01-23 DOI:10.1016/j.ghir.2025.101637

Cheryl A. Conover

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引用次数: 0

摘要

细胞衰老及其伴随的分泌组对哺乳动物的生长和衰老具有重要影响。一种新型蛋白酶PAPP-A调节重要生长因子胰岛素样生长因子(IGF)- 1的生物利用度，对生长和衰老有重要影响。本文将从新的角度探讨细胞衰老与PAPP-A的关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Cellular senescence and PAPP-A

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Cellular senescence and PAPP-A

Cellular senescence and its accompanying secretome have major impact on growth and aging of mammalian organisms. A novel protease, PAPP-A, regulates the bioavailability of an important growth factor, insulin-like growth factor (IGF)-I, and has major impact on growth and aging. This short review will explore a new perspective of cellular senescence and PAPP-A.

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来源期刊

Growth Hormone & Igf Research 医学-内分泌学与代谢

CiteScore

3.30

自引率

0.00%

发文量

审稿时长

57 days

期刊介绍： Growth Hormone & IGF Research is a forum for research on the regulation of growth and metabolism in humans, animals, tissues and cells. It publishes articles on all aspects of growth-promoting and growth-inhibiting hormones and factors, with particular emphasis on insulin-like growth factors (IGFs) and growth hormone. This reflects the increasing importance of growth hormone and IGFs in clinical medicine and in the treatment of diseases.