医学上的胸膜粘连病例中潜伏结核和分枝杆菌感染的患病率:一项观察性研究

Q3 Medicine
Jayanthi Yadav , Ujjawal Khurana , Shubham Richariya , Shashank Purwar , Sangita Moirangthem , Johann Aibantyllilang Blah
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引用次数: 0

摘要

目的和背景胸膜粘连,即胸膜层之间的纤维带,在尸检中很常见,通常与肺结核(TB)有关。本研究旨在确定医学上胸膜粘连病例中潜伏性结核和分枝杆菌感染的患病率。重点是各种诊断方法和该研究对印度等高负担国家结核病管理的影响。材料和方法这项观察性研究历时两年,涉及博帕尔医学研究所的743例尸体解剖。我们对82例胸膜粘连患者的组织样本进行了分析。诊断方法包括直接涂片镜检、分枝杆菌生长指示剂(MGIT)、Lowenstein-Jensen培养基(LJ)和PCR。164例胸膜粘连患者中分枝杆菌阳性15例(18.29 %),其中MTB 11例,NTM 4例。诊断方法揭示了检测潜伏性结核病的挑战。偶然诊断很普遍,强调需要提高认识。先进的技术(MGIT、LJ、PCR)提高了检出率。这项研究突出了潜伏性结核病在印度的影响,表明了研究、监测和干预措施对有效控制结核病的重要性。处理潜伏性结核病在全球根除工作中至关重要。结论该研究强调印度的结核病负担,胸膜粘连可作为临床标志。偶然诊断和潜伏性结核病在人群中的作用强调了加强研究和诊断策略的必要性。诊断方面的挑战,包括有限的症状,需要先进的技术。该研究讨论了潜伏性结核病诊断的多方面挑战和干预措施的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Prevalence of latent tuberculosis and mycobacterial infections in medicolegal cases with pleural adhesions: An observational study

Objective and Background

Pleural adhesions, fibrous bands between pleural layers, are common in autopsies and often associated with Tuberculosis (TB). This study aims to determine the prevalence of latent TB and mycobacterial infections in medicolegal cases with pleural adhesions. The focus is on various diagnostic approaches and implications of the study for TB management in a high-burden setting like India.

Materials and Methods

The observational study spanned two years, involving 743 autopsies at AIIMS Bhopal. Tissue samples from 82 cases with pleural adhesions were analyzed after obtaining consent and a detailed history. Diagnostic methods, including direct smear microscopy, Mycobacteria Growth Indicator (MGIT), Lowenstein–Jensen (LJ) media, and PCR, were employed.

Observation

Of 164 cases with pleural adhesions, 15 (18.29 %) were positive for Mycobacterium, including 11 MTB and 4 NTM cases. Diagnostic methods revealed the challenges in detecting latent TB. Incidental diagnoses were prevalent, emphasizing the need for heightened awareness. Advanced techniques (MGIT, LJ, PCR) improved detection rates. The study highlights latent TB's impact in India, suggesting the importance of research, surveillance, and interventions for effective TB control. Addressing latent TB becomes crucial in global eradication efforts.

Conclusion

The study emphasizes India's TB burden, with pleural adhesions acting as clinical markers. Incidental diagnoses and the role of latent TB in the population underscore the need for enhanced research and diagnostic strategies. Diagnostic challenges, including limited symptoms, necessitate advanced techniques. The study discusses the multifaceted challenge of latent TB diagnosis and the importance of interventions.
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来源期刊
Forensic Science International: Reports
Forensic Science International: Reports Medicine-Pathology and Forensic Medicine
CiteScore
2.40
自引率
0.00%
发文量
47
审稿时长
57 days
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