Nam M.P. Tran, Anh T.H. Truong, Dang T. Nguyen, Tram T. Dang
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引用次数: 0
摘要
蛋白酶在调节炎症中起着至关重要的作用,但它们对植入材料免疫反应的影响尚未得到充分研究。在文章编号2309709中,Nam Tran, Anh Truong, Dang Nguyen和Tram Dang全面分析了免疫能力小鼠对各种微颗粒物质的蛋白酶反应,揭示了蛋白酶活性与促炎细胞因子表达之间的强相关性。封面插图捕捉了不同材料如何触发不同水平的蛋白酶活性,作为材料诱导免疫反应的非侵入性生物分子特征来测量。
Profiling Pro-Inflammatory Proteases as Biomolecular Signatures of Material-Induced Subcutaneous Host Response in Immuno-Competent Mice (Adv. Sci. 5/2025)
Proteases in Material-Induced Immune Response
Proteases play a crucial role in modulating inflammation, yet their influence on immune reactions to implanted materials is understudied. In article number 2309709, Nam Tran, Anh Truong, Dang Nguyen, and Tram Dang comprehensively profile protease responses to various microparticulate materials in immuno-competent mice, revealing a strong correlation between protease activity and expression of pro-inflammatory cytokines. The cover artwork captures how different materials trigger distinct levels of protease activity, measurable as a non-invasive biomolecular signature of material-induced immune response.
期刊介绍:
Advanced Science is a prestigious open access journal that focuses on interdisciplinary research in materials science, physics, chemistry, medical and life sciences, and engineering. The journal aims to promote cutting-edge research by employing a rigorous and impartial review process. It is committed to presenting research articles with the highest quality production standards, ensuring maximum accessibility of top scientific findings. With its vibrant and innovative publication platform, Advanced Science seeks to revolutionize the dissemination and organization of scientific knowledge.