三组分反应合成新型噻唑[4,5-e]吲哚衍生物

IF 2 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Journal of Chemical Sciences Pub Date : 2025-01-29 DOI:10.1007/s12039-024-02345-8

Bing-Wei Wang, Ming-Han Huang, Xue Wang, Dong-Sheng Chen

引用次数: 0

摘要

以2-甲基苯并[d]噻唑-5-胺、芳基乙二醛一水合物和环己烷-1,3-二酮为原料，在乙醇介质中以乙酸为催化剂，在80℃条件下进行了三组分多米诺骨牌反应，得到了一系列噻唑[4,5-e]吲哚衍生物。该合成工艺具有反应温和、合成效率高、后处理操作简单、副产物仅为水等特点。合成噻唑[4,5-e]吲哚衍生物的新方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Simple and efficient synthesis of novel thiazolo[4,5-e]indole derivatives via three-component reaction

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Simple and efficient synthesis of novel thiazolo[4,5-e]indole derivatives via three-component reaction

A series of thiazolo[4,5-e]indole derivatives have been obtained by a three-component domino reaction of 2-methylbenzo[d]thiazol-5-amine, arylglyoxal monohydrates and cyclohexane-1,3-dione in ethanol medium at 80°C catalyzed by acetic acid. Notable features of this synthesis are mild reaction, high synthesis efficiency, simple post-treatment operation and only water is generated as a byproduct.

Graphical abstract

A new procedure for the synthesis of thiazolo[4,5-e]indole derivatives.

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来源期刊

Journal of Chemical Sciences CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

3.10

自引率

5.90%

发文量

107

审稿时长

1 months

期刊介绍： Journal of Chemical Sciences is a monthly journal published by the Indian Academy of Sciences. It formed part of the original Proceedings of the Indian Academy of Sciences – Part A, started by the Nobel Laureate Prof C V Raman in 1934, that was split in 1978 into three separate journals. It was renamed as Journal of Chemical Sciences in 2004. The journal publishes original research articles and rapid communications, covering all areas of chemical sciences. A significant feature of the journal is its special issues, brought out from time to time, devoted to conference symposia/proceedings in frontier areas of the subject, held not only in India but also in other countries.