将查耳酮、N-对甲苯磺酰肼和 KSCN/KSeCN 模块化组装以合成三取代咪唑并[2,1-b][1,3,4]噻二唑/硒二唑

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-02-03 DOI:10.1021/acs.orglett.4c04786

Guojin Sun, Lang Liu, Jun Zhang, Zhe Zhang, Mengyao She, Jiao Chen, Ping Liu, Shengyong Zhang, Jianli Li

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引用次数: 0

摘要

提出了一种模块化的方法，通过易于获得的n -甲酰基腙、查尔酮衍生物和KSCN/KSeCN，实现了咪唑[2,1-b][1,3,4]噻二唑/硒二唑的高效合成。该方法克服了以往方法合成步骤冗长和预功能化的缺点。解决了传统制备方法难以合成增稠含硒杂环分子的问题，进一步扩大了其家族成员的数量。这些化合物的荧光也揭示了我们合成的支架的潜在价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Modular Assembly of Chalcones, N-Tosylhydrazones, and KSCN/KSeCN for the Synthesis of Trisubstituted Imidazo[2,1-b][1,3,4]thiadiazoles/selenadiazoles

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Modular Assembly of Chalcones, N-Tosylhydrazones, and KSCN/KSeCN for the Synthesis of Trisubstituted Imidazo[2,1-b][1,3,4]thiadiazoles/selenadiazoles

A modular protocol that achieved the efficient synthesis of imidazo[2,1-b][1,3,4]thiadiazoles/selenadiazoles via using easily available N-tosylhydrazones, chalcone derivatives, and KSCN/KSeCN is proposed. The method overcomes the elongated synthesis steps and prefunctionalized synthons of previous methods. It solves the problem of traditional preparation methods, which makes it difficult to synthesize thickened selenium-containing heterocyclic molecules, further expanding the number of members in its family. The fluorescence of these compounds also reveals the potential values of the scaffolds we synthesized.

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.