3d打印具有放射性准直腔的膜外不透射线斑块，用于近距离治疗中增强剂量的传递。

IF 1.7 4区医学 Q4 ONCOLOGY

Brachytherapy Pub Date : 2025-03-01 DOI:10.1016/j.brachy.2024.12.001

Souheib Zekraoui , Théophraste Lescot , Mahdokht Akbari Taemeh , Marc-André Fortin

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引用次数: 0

摘要

目的：巩膜斑块近距离放射治疗（EPBT）是一种成熟的治疗方法。然而，对健康组织（如巩膜、视网膜和视神经）的侧向剂量往往是有问题的，并导致副作用。本研究提出了一种基于3d打印的不透明聚合物斑块的创新方法，该斑块具有圆柱形放射性腔（CRC），对肿瘤的辐射输送具有潜在的准直作用。方法和材料：基于COMS协议创建CAD模型，并使用不透射线的PEEK聚合物进行3d打印。在牙菌斑的内表面均匀分布圆柱形空腔（1毫米深/直径）。两种放射性布局(RL1：均匀加载；RL2：径向梯度加载)。µCT成像用于评估3d打印CRC EPs的几何精度，并使用MAGIC-pf凝胶剂量法和t2加权MRI评估两(2)种放射性布局的剂量分布。将COMS和SEP斑块产生的剂量谱进行比较。结果：与COMS和SEP斑块相比，不透射线的CRC EPs显示出更高的中轴剂量沉积，同时最大限度地减少了侧向过度暴露，同时还提供了强大的反向屏蔽。RL1 CRC EPs的剂量分布（均匀分布）向眼内延伸更深，而RL2 CRC EPs（梯度分布）的剂量下降更快，形成集中的球形剂量分布。结论：在圆柱形腔中封装放射性的3d打印不透射线EPs显示出在EPBT中获得更多正向投射剂量谱的能力。这种制造设计和整个EP表面的调制放射性分布将实现更精确和更深的剂量传递，同时减少辐射暴露于侧面健康组织。

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3D-printed radiopaque episcleral plaques with radioactive collimating cavities for enhanced dose delivery in brachytherapy

PURPOSE

Episcleral plaque brachytherapy (EPBT) is a well-established treatment. However, the lateral dose to healthy tissues, such as the sclera, retina, and optic nerve is often problematic and results in side effects. This study proposes an innovative approach based on the 3D-printing of radiopaque polymer plaques featuring cylindrical radioactive cavities (CRC) with a potential collimating effect on radiation delivery to tumors.

METHODS AND MATERIALS

A CAD model based on the COMS protocol was created and 3D-printed using radiopaque PEEK polymer. Cylindrical cavities (1 mm depth/diameter) were evenly spaced on the plaque's inner surface. Two radioactive layouts (RL₁: uniform loading; RL₂: radial gradient loading) were designed. µCT imaging was used to assess the geometric accuracy of the 3D-printed CRC EPs, and dose distribution was evaluated for the two (2) radioactive layouts using MAGIC-pf gel dosimetry and T₂-weighted MRI. The resulting dose profiles were compared with those generated by both COMS and SEP plaques.

RESULTS

Radiopaque CRC EPs showed higher central axis dose deposition while minimizing lateral overexposure compared to COMS and SEP plaques, while also providing robust back-shielding. Dose profiles from RL₁ CRC EPs (uniform layout) extended deeper into the eye, whereas RL₂ CRC EPs (with gradient) exhibited a more rapid dose fall-off, producing a concentrated, spherical dose distribution.

CONCLUSIONS

3D-printed radiopaque EPs with radioactivity encapsulated in cylindrical cavities demonstrated the ability to achieve more forward-projected dose profiles in EPBT. This fabrication design and a modulated radioactivity distribution across the EP surface would enable more precise and deeper dose delivery while reducing radiation exposure to lateral healthy tissues.

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来源期刊

Brachytherapy 医学-核医学

CiteScore

3.40

自引率

21.10%

发文量

119

审稿时长

9.1 weeks

期刊介绍： Brachytherapy is an international and multidisciplinary journal that publishes original peer-reviewed articles and selected reviews on the techniques and clinical applications of interstitial and intracavitary radiation in the management of cancers. Laboratory and experimental research relevant to clinical practice is also included. Related disciplines include medical physics, medical oncology, and radiation oncology and radiology. Brachytherapy publishes technical advances, original articles, reviews, and point/counterpoint on controversial issues. Original articles that address any aspect of brachytherapy are invited. Letters to the Editor-in-Chief are encouraged.