自闭症谱系障碍的药物治疗:治疗指南的系统回顾。

IF 3.6 3区 医学 Q2 PHARMACOLOGY & PHARMACY
Pharmacopsychiatry Pub Date : 2025-05-01 Epub Date: 2025-01-31 DOI:10.1055/a-2514-4452
Sota Tomiyama, Kazunari Yoshida, Hideaki Tani, Hiroyuki Uchida
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引用次数: 0

摘要

目前可获得的关于自闭症谱系障碍(ASD)药物治疗的系统综述并未涵盖所有证据,因为它们排除了国家或地方当局发布的未在PubMed等搜索引擎中编入索引的指南。使用EMBASE、Medline和PsycINFO进行了系统的文献检索,以确定关于该主题的临床指南。还进行了人工检索,以查明未列入上述数据库的国家或地方当局的准则。通过人工检索确定了38项指导方针,其中搜索引擎27项,一般指导方针2项,政府机构指导方针9项。许多指南推荐利培酮(N=16)用于ASD核心特征的特征性行为。对于注意力缺陷/多动障碍(ADHD)的特征,哌醋甲酯最常被推荐用于治疗注意力不集中(N=6)和多动/冲动(N=16)。利培酮也经常被推荐用于适应不良行为(N=33)。全面的文献检索确定了地方或国家行政机构发布的ASD治疗指南,这些指南不是单独通过搜索引擎获取的。在使用精神药物减轻ASD特定特征的指南中有一些共识。然而,医生需要意识到缺乏高质量的证据来支持这些建议。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Pharmacological Treatment of Autism Spectrum Disorder: A Systematic Review of Treatment Guidelines.

Currently available systematic reviews on the pharmacological treatment of autism spectrum disorder (ASD) do not encompass all the evidence, as they exclude guidelines issued by national or local authorities that are not indexed in search engines such as PubMed.A systematic literature search was conducted to identify clinical guidelines on this topic using EMBASE, Medline, and PsycINFO. A manual search was also performed to identify guidelines by national or local authorities not included in the aforementioned databases.Thirty-eight guidelines were identified through manual search, including 27 items through search engines, 2 general guidelines, and 9 government agency guidelines. Many guidelines recommended risperidone (N=16) for the characteristic behaviors of ASD core features. For attention-deficit/hyperactivity disorder (ADHD) features, methylphenidate was most frequently recommended (N=23) for both inattention (N=6) and hyperactivity/impulsivity (N=16). Risperidone was also frequently recommended for maladaptive behaviors (N=33).A comprehensive literature search identified treatment guidelines for ASD issued by local or national administrative bodies that were not captured through search engines alone. There was some consensus among the guidelines on the use of psychotropics in alleviating specific features of ASD. However, physicians need to be aware of the lack of high-quality evidence supporting these recommendations.

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来源期刊
Pharmacopsychiatry
Pharmacopsychiatry 医学-精神病学
CiteScore
7.10
自引率
9.30%
发文量
54
审稿时长
6-12 weeks
期刊介绍: Covering advances in the fi eld of psychotropic drugs, Pharmaco psychiatry provides psychiatrists, neuroscientists and clinicians with key clinical insights and describes new avenues of research and treatment. The pharmacological and neurobiological bases of psychiatric disorders are discussed by presenting clinical and experimental research.
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