两性霉素B脂质体与补体激活相关的假过敏（CARPA）。

IF 4.1 2区医学 Q2 MICROBIOLOGY

Antimicrobial Agents and Chemotherapy Pub Date : 2025-03-05 Epub Date: 2025-01-30 DOI:10.1128/aac.01692-24

George R Thompson, Gelina M Sani, Monica A Donnelley, Jaimie K Figueroa, Ryan Ciuffetelli, Kate Trigg, Juan Arredondo, Alan Koff, Marie Nearing, Ikaika C Loque, Derek J Bays, Satya Dandekar

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引用次数: 0

摘要

与两性霉素B脂质体相关的输注反应（心动过速、高血压、发热等）很常见。动物模型已经发现补体激活起作用，但尚未对人类患者的病理生理学进行评估。我们进行了一项前瞻性观察研究，发现补体激活相关的假过敏（CARPA）与输液反应有关。

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Liposomal amphotericin B and complement activation-related pseudoallergy (CARPA).

Infusion reactions (tachycardia, hypertension, fever, etc.) associated with liposomal amphotericin B are common. Animal models have found complement activation responsible, yet the pathophysiology has not been evaluated in human patients. We performed a prospective observational study and found complement activation-related pseudoallergy (CARPA) responsible in those with infusion reactions.

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来源期刊

Antimicrobial Agents and Chemotherapy 医学-微生物学

CiteScore

10.00

自引率

8.20%

发文量

762

审稿时长

3 months

期刊介绍： Antimicrobial Agents and Chemotherapy (AAC) features interdisciplinary studies that build our understanding of the underlying mechanisms and therapeutic applications of antimicrobial and antiparasitic agents and chemotherapy.