{"title":"未来展望：骨/软骨类器官技术的进展和临床潜力。","authors":"Jingtao Huang, Aikang Li, Rongji Liang, Xiaohao Wu, Shicheng Jia, Jiayou Chen, Zilu Jiao, Canfeng Li, Xintao Zhang, Jianjing Lin","doi":"10.12336/biomatertransl.2024.04.007","DOIUrl":null,"url":null,"abstract":"<p><p>Bone and cartilage tissues are essential for movement and structure, yet diseases like osteoarthritis affect millions. Traditional therapies have limitations, necessitating innovative approaches. Organoid technology, leveraging stem cells' regenerative potential, offers a novel platform for disease modelling and therapy. This review focuses on advancements in bone/cartilage organoid technology, highlighting the role of stem cells, biomaterials, and external factors in organoid development. We discuss the implications of these organoids for regenerative medicine, disease research, and personalised treatment strategies, presenting organoids as a promising avenue for enhancing cartilage repair and bone regeneration. Bone/cartilage organoids will play a greater role in the treatment of bone/cartilage diseases in the future, and promote the progress of biological tissue engineering.</p>","PeriodicalId":58820,"journal":{"name":"Biomaterials Translational","volume":"5 4","pages":"425-443"},"PeriodicalIF":0.0000,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11764185/pdf/","citationCount":"0","resultStr":"{\"title\":\"Future perspectives: advances in bone/cartilage organoid technology and clinical potential.\",\"authors\":\"Jingtao Huang, Aikang Li, Rongji Liang, Xiaohao Wu, Shicheng Jia, Jiayou Chen, Zilu Jiao, Canfeng Li, Xintao Zhang, Jianjing Lin\",\"doi\":\"10.12336/biomatertransl.2024.04.007\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Bone and cartilage tissues are essential for movement and structure, yet diseases like osteoarthritis affect millions. Traditional therapies have limitations, necessitating innovative approaches. Organoid technology, leveraging stem cells' regenerative potential, offers a novel platform for disease modelling and therapy. This review focuses on advancements in bone/cartilage organoid technology, highlighting the role of stem cells, biomaterials, and external factors in organoid development. We discuss the implications of these organoids for regenerative medicine, disease research, and personalised treatment strategies, presenting organoids as a promising avenue for enhancing cartilage repair and bone regeneration. Bone/cartilage organoids will play a greater role in the treatment of bone/cartilage diseases in the future, and promote the progress of biological tissue engineering.</p>\",\"PeriodicalId\":58820,\"journal\":{\"name\":\"Biomaterials Translational\",\"volume\":\"5 4\",\"pages\":\"425-443\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-11-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11764185/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biomaterials Translational\",\"FirstCategoryId\":\"1087\",\"ListUrlMain\":\"https://doi.org/10.12336/biomatertransl.2024.04.007\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomaterials Translational","FirstCategoryId":"1087","ListUrlMain":"https://doi.org/10.12336/biomatertransl.2024.04.007","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
Future perspectives: advances in bone/cartilage organoid technology and clinical potential.
Bone and cartilage tissues are essential for movement and structure, yet diseases like osteoarthritis affect millions. Traditional therapies have limitations, necessitating innovative approaches. Organoid technology, leveraging stem cells' regenerative potential, offers a novel platform for disease modelling and therapy. This review focuses on advancements in bone/cartilage organoid technology, highlighting the role of stem cells, biomaterials, and external factors in organoid development. We discuss the implications of these organoids for regenerative medicine, disease research, and personalised treatment strategies, presenting organoids as a promising avenue for enhancing cartilage repair and bone regeneration. Bone/cartilage organoids will play a greater role in the treatment of bone/cartilage diseases in the future, and promote the progress of biological tissue engineering.
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